PDF(Pubmed)
Abstract：
At a great many locations worldwide, the safety of drinking water is not assured due to pollution with arsenic. Arsenic toxicity is a matter of both systems chemistry and systems biology: it is determined by complex and intertwined networks of chemical reactions in the inanimate environment, in microbes in that environment, and in the human body. We here review what is known about these networks and their interconnections. We then discuss how consideration of the systems aspects of arsenic levels in groundwater may open up new avenues towards the realization of safer drinking water. Along such avenues, both geochemical and microbiological conditions can optimize groundwater microbial ecology vis-à-vis reduced arsenic toxicity.
摘要：
在世界各地的许多地方，由于砷污染，饮用水的安全得不到保证。砷毒性是系统化学和系统生物学的问题：它是由无生命环境中复杂而交织的化学反应网络决定的，在那个环境中的微生物中，在人体中。我们在这里回顾一下有关这些网络及其互连的知识。然后，我们讨论如何考虑地下水中砷含量的系统方面，可以为实现更安全的饮用水开辟新的途径。沿着这样的道路，地球化学和微生物条件都可以优化地下水微生物生态，以减少砷的毒性。
