PDF(Pubmed)
Abstract：
The increase in incidence of superficial fungal infections combined with the emergence of antifungal resistance represents both a global health challenge and a considerable economic burden. Recently, dermatophytes, the main culprit causing superficial fungal infections, have started to exhibit antifungal resistance. This can be observed in some of the most common species such as Trichophyton rubrum and Trichophyton mentagrophytes. Importantly, the new subspecies, known as Trichophyton indotineae, has been reported to show high resistance to terbinafine, a first-line treatment for dermatophyte infections. Compounding these issues is the realization that diagnosing the causative infectious agents requires using molecular analysis that goes beyond the conventional macroscopic and microscopic methods. These findings emphasize the importance of conducting antifungal susceptibility testing to select the appropriate antifungal necessary for successful treatment. Implementing these changes may improve clinical practices that combat resistant dermatophyte infections.
摘要：
浅表真菌感染发病率的增加以及抗真菌药物耐药性的出现代表了全球健康挑战和相当大的经济负担。最近,皮肤癣菌，导致浅表真菌感染的罪魁祸首,已经开始表现出抗真菌抗性。这可以在一些最常见的物种中观察到，例如红色毛癣菌和毛癣菌。重要的是,新的亚种，被称为吲哚毛癣菌，据报道对特比萘芬表现出很高的耐药性，皮肤癣菌感染的一线治疗。使这些问题复杂化的是认识到诊断致病传染原需要使用超越常规宏观和微观方法的分子分析。这些发现强调了进行抗真菌药敏试验以选择成功治疗所需的适当抗真菌药物的重要性。实施这些变化可能会改善对抗耐药性皮肤癣菌感染的临床实践。
