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Abstract：
Endometriosis is a benign, estrogen-dependent gynecological condition with an uncertain exact pathogenetic mechanism. The aim of this study was to evaluate the potential differential expression of Insulin Growth Factor 1 (IGF-1) isoforms in deeply infiltrating endometriotic (DIE) lesions, in ovarian endometriomas, and in the eutopic endometrium of the same endometriosis patients and to compare their expression with that in the eutopic endometrium of women without endometriosis. A total of 39 patients were included: 28 with endometriosis, of whom 15 had endometriomas only, 7 had DIE nodules only, and 6 had both DIE and endometriomas, and 11 without endometriosis served as controls. We noticed a similar pattern of expression between IGF-1Ea and IGF-1Ec, which differed from that of the IGF-1Eb isoform, possibly implying differential biological actions of different isoforms in DIE subtypes. We observed a tendency of lower expression of IGF-1Ea and IGF-1Ec in endometriomas without DIE compared to endometriomas with concurrent DIE or in DIE nodules. In conclusion, differential expression of IGF-1 isoforms may indicate that DIE with its associated ovarian lesions and simple ovarian endometriosis should be considered as two forms of the disease developing under different molecular pathways.
摘要：
子宫内膜异位症是良性的，雌激素依赖性妇科疾病，确切的发病机制不确定。这项研究的目的是评估胰岛素生长因子1（IGF-1）亚型在深度浸润性子宫内膜异位（DIE）病变中的潜在差异表达，在卵巢子宫内膜瘤中，在相同子宫内膜异位症患者的在位子宫内膜中，并将其表达与无子宫内膜异位症妇女的在位子宫内膜中的表达进行比较。共纳入39例患者：28例子宫内膜异位症，其中15人仅患有子宫内膜瘤，7只有死结节，6人同时患有死亡和子宫内膜瘤，11个无子宫内膜异位症作为对照。我们注意到IGF-1Ea和IGF-1Ec的表达模式相似，与IGF-1Eb同工型不同，可能暗示DIE亚型中不同亚型的差异生物学作用。与伴有DIE或DIE结节的子宫内膜瘤相比，我们观察到无DIE的子宫内膜瘤中IGF-1Ea和IGF-1Ec表达较低的趋势。总之,IGF-1亚型的差异表达可能表明DIE及其相关的卵巢病变和单纯性卵巢子宫内膜异位症应被视为在不同分子途径下发展的两种疾病形式。
