PDF(Pubmed)
Abstract：
Acute leukemias, mainly consisting of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), comprise a major diagnostic group among hematologic cancers. Due to the early age at onset of ALL, particularly, it has long been suspected that acute leukemias of childhood may have an in utero origin. This supposition has motivated many investigations seeking direct proof of prenatal leukemogenesis, in particular, twin and \"backtracking studies\". The suspected in utero origin has also focused on gestation as a critical window of risk, resulting in a rich literature on prenatal risk factors for pediatric acute leukemias. In this narrative review, we recount the circumstantial and direct evidence for an in utero origin of childhood acute leukemias.
摘要：
急性白血病,主要包括急性淋巴细胞白血病（ALL）和急性髓系白血病（AML），包括血液系统癌症中的主要诊断组。由于ALL发病年龄较早，特别是,长期以来，人们一直怀疑儿童急性白血病可能起源于子宫内。这种假设促使许多调查寻求产前白血病发生的直接证明，特别是,双胞胎和“回溯研究”。疑似宫内起源也将妊娠作为一个关键的风险窗口，导致了关于小儿急性白血病的产前危险因素的丰富文献。在这篇叙述性评论中，我们叙述了儿童急性白血病子宫内起源的间接和直接证据。
