PDF(Pubmed)
Abstract：
UNASSIGNED: Diagnosis of Menière\'s disease (MD) relies on subjective factors and the patients diagnosed with MD may have heterogeneous pathophysiologies. This study aims to stratify MD patients using two objective data, nystagmus videos and contrast-enhanced magnetic resonance imaging (CE-MRI).
UNASSIGNED: This is a retrospective cross-sectional study. According to the Japan Society for Equilibrium Research criteria (c-JSER), adults diagnosed with definite MD and who obtained videos recorded by portable nystagmus recorder immediately following vertigo attacks and underwent CE-MRI of the inner ear were included (ss = 91). Patients who obtained no nystagmus videos, who had undergone sac surgery, and those with long examination intervals were excluded (n = 40).
UNASSIGNED: The gender of the subjects was 22 males and 29 females. The age range was 20-82 y, with a median of 54 y. Endolymphatic hydrops (EH) were observed on CE-MRI in 84% (43 patients). Thirty-one patients had unilateral EH. All of them demonstrated EH on the side of the presence of cochlear symptoms. The number of patients who had both nystagmus and EH was 38. Five patients only showed EH and 5 patients only exhibited nystagmus, while 3 patients did not have either. Of the 43 nystagmus records, 32 showed irritative nystagmus immediately after the vertigo episode. The direction of nystagmus later reversed in 44% of cases over 24 h.
UNASSIGNED: Patients were stratified into subgroups based on the presence or absence of EH and nystagmus. The side with cochlear symptoms was consistent with EH. The c-JSER allows for the diagnosis of early-stage MD patients, and it can be used to treat early MD and preserve hearing; however, this approach may also include patients with different pathologies.
UNASSIGNED: This is a retrospective cross-sectional study. According to the Japan Society for Equilibrium Research criteria (c-JSER), adults diagnosed with definite MD and who obtained videos recorded by portable nystagmus recorder immediately following vertigo attacks and underwent CE-MRI of the inner ear were included (ss = 91). Patients who obtained no nystagmus videos, who had undergone sac surgery, and those with long examination intervals were excluded (n = 40).
UNASSIGNED: The gender of the subjects was 22 males and 29 females. The age range was 20-82 y, with a median of 54 y. Endolymphatic hydrops (EH) were observed on CE-MRI in 84% (43 patients). Thirty-one patients had unilateral EH. All of them demonstrated EH on the side of the presence of cochlear symptoms. The number of patients who had both nystagmus and EH was 38. Five patients only showed EH and 5 patients only exhibited nystagmus, while 3 patients did not have either. Of the 43 nystagmus records, 32 showed irritative nystagmus immediately after the vertigo episode. The direction of nystagmus later reversed in 44% of cases over 24 h.
UNASSIGNED: Patients were stratified into subgroups based on the presence or absence of EH and nystagmus. The side with cochlear symptoms was consistent with EH. The c-JSER allows for the diagnosis of early-stage MD patients, and it can be used to treat early MD and preserve hearing; however, this approach may also include patients with different pathologies.
摘要：
■梅尼埃病（MD）的诊断依赖于主观因素，诊断为MD的患者可能具有异质性的病理生理。本研究旨在使用两个客观数据对MD患者进行分层，眼球震颤视频和对比增强磁共振成像（CE-MRI）。
■这是一项回顾性的横断面研究。根据日本均衡研究协会(c-JSER)的标准，纳入诊断为明确MD的成年人,在眩晕发作后立即获得便携式眼球震颤记录仪记录的视频,并接受内耳CE-MRI检查(ss=91).没有获得眼球震颤视频的患者，接受了囊手术的人，排除检查间隔较长的患者(n=40)。
■受试者的性别为22名男性和29名女性。年龄范围为20-82岁，中位数为54y。在CE-MRI上观察到84%(43例患者)的内淋巴积液(EH)。31例患者出现单侧EH。所有患者均表现出EH一侧存在耳蜗症状。同时患有眼球震颤和EH的患者人数为38。5例仅显示EH，5例仅显示眼球震颤，而3例患者也没有。在43个眼球震颤记录中,32在眩晕发作后立即显示刺激性眼震。眼震的方向后来在24小时内逆转了44％的病例。
■根据是否存在EH和眼球震颤将患者分为亚组。有耳蜗症状的一侧与EH一致。c-JSER可以诊断早期MD患者，它可用于治疗早期MD并保留听力；然而，这种方法也可能包括具有不同病理的患者。
■这是一项回顾性的横断面研究。根据日本均衡研究协会(c-JSER)的标准，纳入诊断为明确MD的成年人,在眩晕发作后立即获得便携式眼球震颤记录仪记录的视频,并接受内耳CE-MRI检查(ss=91).没有获得眼球震颤视频的患者，接受了囊手术的人，排除检查间隔较长的患者(n=40)。
■受试者的性别为22名男性和29名女性。年龄范围为20-82岁，中位数为54y。在CE-MRI上观察到84%(43例患者)的内淋巴积液(EH)。31例患者出现单侧EH。所有患者均表现出EH一侧存在耳蜗症状。同时患有眼球震颤和EH的患者人数为38。5例仅显示EH，5例仅显示眼球震颤，而3例患者也没有。在43个眼球震颤记录中,32在眩晕发作后立即显示刺激性眼震。眼震的方向后来在24小时内逆转了44％的病例。
■根据是否存在EH和眼球震颤将患者分为亚组。有耳蜗症状的一侧与EH一致。c-JSER可以诊断早期MD患者，它可用于治疗早期MD并保留听力；然而，这种方法也可能包括具有不同病理的患者。
