PDF(Pubmed)
Abstract：
UNASSIGNED: Information on dogs that undergo radiation therapy (RT) with non-stereotactic protocols in addition to surgical stabilization with implant placement for treatment of bone tumors is limited.
UNASSIGNED: Our primary objectives were to describe the clinical characteristics as well as short- and long-term outcomes, including complications, function, and disease progression, in dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor.
UNASSIGNED: A bi-institutional retrospective case series was performed.
UNASSIGNED: Eight client-owned dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor were included.
UNASSIGNED: Tumor types included osteosarcoma or suspected osteosarcoma (5), plasma cell tumor (2), and grade 3 fibrosarcoma (1). Radiation protocols were hypofractionated (palliative intent) in 5 dogs and fractionated (definitive intent) in 3 dogs. Five dogs experienced complications following both RT and surgery, including grade 1 complications in two dogs, a grade 2 complication in one dog, both grade 1 and 2 complications in one dog, and both grade 2 and 3 complications in one dog. Clinical signs subjectively improved in all dogs that had outcomes relative to function documented post-surgery/RT (7). Of these 7 dogs, 4 maintained long-term improvement in function and clinical signs, whereas 3 experienced subsequent recurrence/progression of clinical signs at a median of 133 days (range 91-186) postoperatively in association with biomechanical complications (screw loosening), surgical site infection, and local disease progression in 1 dog each; subsequent treatment resulted in improved clinical signs for each of these 3 dogs, such that overall good long-term functional outcomes were experienced. No dogs required amputation or additional vertebral surgery as salvage for local disease control or palliation. The median progression free interval was 206 days (range 25-1078), and the median survival time was 253 days (range 122-1078) with 1 additional dog lost to follow-up at 575 days. Two dogs experienced local disease progression, and 6 dogs experienced systemic disease progression; both dogs that developed local disease progression received palliative intent RT protocols.
UNASSIGNED: In this cohort, dogs with primary bone tumors that underwent surgical stabilization with implant placement and hypofractionated or fractionated non-stereotactic RT for local treatment had a low incidence of major complications, good limb function and ambulation post-treatment, and relatively prolonged survival times despite disease progression.
UNASSIGNED: Our primary objectives were to describe the clinical characteristics as well as short- and long-term outcomes, including complications, function, and disease progression, in dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor.
UNASSIGNED: A bi-institutional retrospective case series was performed.
UNASSIGNED: Eight client-owned dogs that underwent both surgical stabilization with implant placement and non-stereotactic RT for local treatment of a bone tumor were included.
UNASSIGNED: Tumor types included osteosarcoma or suspected osteosarcoma (5), plasma cell tumor (2), and grade 3 fibrosarcoma (1). Radiation protocols were hypofractionated (palliative intent) in 5 dogs and fractionated (definitive intent) in 3 dogs. Five dogs experienced complications following both RT and surgery, including grade 1 complications in two dogs, a grade 2 complication in one dog, both grade 1 and 2 complications in one dog, and both grade 2 and 3 complications in one dog. Clinical signs subjectively improved in all dogs that had outcomes relative to function documented post-surgery/RT (7). Of these 7 dogs, 4 maintained long-term improvement in function and clinical signs, whereas 3 experienced subsequent recurrence/progression of clinical signs at a median of 133 days (range 91-186) postoperatively in association with biomechanical complications (screw loosening), surgical site infection, and local disease progression in 1 dog each; subsequent treatment resulted in improved clinical signs for each of these 3 dogs, such that overall good long-term functional outcomes were experienced. No dogs required amputation or additional vertebral surgery as salvage for local disease control or palliation. The median progression free interval was 206 days (range 25-1078), and the median survival time was 253 days (range 122-1078) with 1 additional dog lost to follow-up at 575 days. Two dogs experienced local disease progression, and 6 dogs experienced systemic disease progression; both dogs that developed local disease progression received palliative intent RT protocols.
UNASSIGNED: In this cohort, dogs with primary bone tumors that underwent surgical stabilization with implant placement and hypofractionated or fractionated non-stereotactic RT for local treatment had a low incidence of major complications, good limb function and ambulation post-treatment, and relatively prolonged survival times despite disease progression.
摘要：
■关于狗的信息是有限的，除了手术稳定和植入物放置以治疗骨肿瘤之外，还使用非立体定向方案进行放射治疗（RT）。
■我们的主要目标是描述临床特征以及短期和长期结果，包括并发症,函数,和疾病进展，在犬中，既接受了通过植入物放置的手术稳定治疗，也接受了非立体定向RT治疗的骨肿瘤。
■进行了双机构回顾性病例系列。
■包括8只接受植入手术稳定和非立体定向RT治疗骨肿瘤的犬。
■肿瘤类型包括骨肉瘤或疑似骨肉瘤（5），浆细胞肿瘤(2)，3级纤维肉瘤（1）。辐射方案在5只狗中进行了低分割（姑息意图），在3只狗中进行了分割（确定意图）。五只狗在RT和手术后都出现了并发症，包括两只狗的1级并发症，一只狗的二级并发症，一只狗的1级和2级并发症，一只狗的2级和3级并发症。在具有相对于手术后/RT记录的功能的结果的所有狗中,临床体征主观地改善(7)。在这7只狗中，4维持功能和临床体征的长期改善，而3例患者在术后中位133天（范围91-186）的临床体征随后复发/进展与生物力学并发症（螺钉松动）相关，手术部位感染,和局部疾病进展在1只狗;随后的治疗导致改善临床症状为每这3只狗,这样就经历了总体良好的长期功能结果。没有狗需要截肢或额外的椎骨手术作为局部疾病控制或缓解的抢救。中位无进展间隔为206天（范围25-1078），中位生存时间为253天（范围122-1078），另外1只狗在575天失去随访。两只狗经历了局部疾病进展，和6只狗经历了全身性疾病进展;发生局部疾病进展的两只狗都接受了姑息性意图RT方案。
■在此队列中，患有原发性骨肿瘤的狗接受了植入物放置和局部治疗的手术稳定以及大分割或分割的非立体定向RT的主要并发症发生率低。良好的肢体功能和步行治疗后，和相对延长的生存时间，尽管疾病进展。
■我们的主要目标是描述临床特征以及短期和长期结果，包括并发症,函数,和疾病进展，在犬中，既接受了通过植入物放置的手术稳定治疗，也接受了非立体定向RT治疗的骨肿瘤。
■进行了双机构回顾性病例系列。
■包括8只接受植入手术稳定和非立体定向RT治疗骨肿瘤的犬。
■肿瘤类型包括骨肉瘤或疑似骨肉瘤（5），浆细胞肿瘤(2)，3级纤维肉瘤（1）。辐射方案在5只狗中进行了低分割（姑息意图），在3只狗中进行了分割（确定意图）。五只狗在RT和手术后都出现了并发症，包括两只狗的1级并发症，一只狗的二级并发症，一只狗的1级和2级并发症，一只狗的2级和3级并发症。在具有相对于手术后/RT记录的功能的结果的所有狗中,临床体征主观地改善(7)。在这7只狗中，4维持功能和临床体征的长期改善，而3例患者在术后中位133天（范围91-186）的临床体征随后复发/进展与生物力学并发症（螺钉松动）相关，手术部位感染,和局部疾病进展在1只狗;随后的治疗导致改善临床症状为每这3只狗,这样就经历了总体良好的长期功能结果。没有狗需要截肢或额外的椎骨手术作为局部疾病控制或缓解的抢救。中位无进展间隔为206天（范围25-1078），中位生存时间为253天（范围122-1078），另外1只狗在575天失去随访。两只狗经历了局部疾病进展，和6只狗经历了全身性疾病进展;发生局部疾病进展的两只狗都接受了姑息性意图RT方案。
■在此队列中，患有原发性骨肿瘤的狗接受了植入物放置和局部治疗的手术稳定以及大分割或分割的非立体定向RT的主要并发症发生率低。良好的肢体功能和步行治疗后，和相对延长的生存时间，尽管疾病进展。
