PDF(Pubmed)
Abstract：
Respiratory viral infections represent a significant global health burden. Historically, influenza, rhinovirus, respiratory syncytial virus, and adenovirus have been the prevalent viruses; however, the landscape shifted with the widespread emergence of SARS-CoV-2. The aim of this study is to present a comprehensive epidemiological analysis of viral respiratory infections in Jalisco, Mexico.
Data encompassing individuals with flu-like symptoms from July 2021 to February 2023 was scrutinized for viral diagnosis through PCR multiplex. The effect of social mobility on the increase in respiratory viral diagnosis infection was considered to estimate its impact. Additionally, sequences of respiratory viruses stored in public databases were retrieved to ascertain the phylogenetic classification of previously reported viruses in Mexico.
SARS-CoV-2 was the most detected virus (n = 5,703; 92.2%), followed by influenza (n = 479; 7.78%). These viruses were also found as the most common co-infection (n = 11; 50%), and for those with influenza, a higher incidence of severe disease was reported (n = 122; 90.4%; p < 0.001). Regarding comorbidities and unhealthy habits, smoking was found to be a risk factor for influenza infection but a protective factor for SARS-CoV-2 (OR = 2.62; IC 95%: 1.66-4.13; OR = 0.65; IC 95%: 0.45-0.94), respectively. Furthermore, our findings revealed a direct correlation between mobility and the prevalence of influenza infection (0.214; p < 0.001).
The study presents evidence of respiratory virus reemergence and prevalence during the social reactivation, facilitating future preventive measures.
Data encompassing individuals with flu-like symptoms from July 2021 to February 2023 was scrutinized for viral diagnosis through PCR multiplex. The effect of social mobility on the increase in respiratory viral diagnosis infection was considered to estimate its impact. Additionally, sequences of respiratory viruses stored in public databases were retrieved to ascertain the phylogenetic classification of previously reported viruses in Mexico.
SARS-CoV-2 was the most detected virus (n = 5,703; 92.2%), followed by influenza (n = 479; 7.78%). These viruses were also found as the most common co-infection (n = 11; 50%), and for those with influenza, a higher incidence of severe disease was reported (n = 122; 90.4%; p < 0.001). Regarding comorbidities and unhealthy habits, smoking was found to be a risk factor for influenza infection but a protective factor for SARS-CoV-2 (OR = 2.62; IC 95%: 1.66-4.13; OR = 0.65; IC 95%: 0.45-0.94), respectively. Furthermore, our findings revealed a direct correlation between mobility and the prevalence of influenza infection (0.214; p < 0.001).
The study presents evidence of respiratory virus reemergence and prevalence during the social reactivation, facilitating future preventive measures.
摘要：
呼吸道病毒感染是全球重大的健康负担。历史上,流感,鼻病毒,呼吸道合胞病毒，和腺病毒一直是流行的病毒；然而，随着SARS-CoV-2的广泛出现，景观发生了变化。这项研究的目的是对哈利斯科州的病毒性呼吸道感染进行全面的流行病学分析，墨西哥。
■通过多重PCR对2021年7月至2023年2月期间有流感样症状的个体的数据进行了审查，以进行病毒诊断。社会流动性对呼吸道病毒感染诊断感染增加的影响被认为是评估其影响。此外,我们检索了存储在公共数据库中的呼吸道病毒序列,以确定墨西哥以前报道的病毒的系统发育分类.
■SARS-CoV-2是检测最多的病毒（n=5,703;92.2％），其次是流感（n=479；7.78%）。这些病毒也被发现是最常见的共感染（n=11;50％），对于那些患有流感的人来说，据报道,严重疾病的发病率较高(n=122;90.4%;p<0.001).关于合并症和不健康的习惯，发现吸烟是流感感染的危险因素，但却是SARS-CoV-2的保护因素（OR=2.62;IC95％：1.66-4.13;OR=0.65;IC95％：0.45-0.94），分别。此外，我们的研究结果揭示了流动性与流感感染率之间的直接相关性(0.214;p<0.001).
■该研究提供了在社会重新激活期间呼吸道病毒重新出现和流行的证据，促进未来的预防措施。
■通过多重PCR对2021年7月至2023年2月期间有流感样症状的个体的数据进行了审查，以进行病毒诊断。社会流动性对呼吸道病毒感染诊断感染增加的影响被认为是评估其影响。此外,我们检索了存储在公共数据库中的呼吸道病毒序列,以确定墨西哥以前报道的病毒的系统发育分类.
■SARS-CoV-2是检测最多的病毒（n=5,703;92.2％），其次是流感（n=479；7.78%）。这些病毒也被发现是最常见的共感染（n=11;50％），对于那些患有流感的人来说，据报道,严重疾病的发病率较高(n=122;90.4%;p<0.001).关于合并症和不健康的习惯，发现吸烟是流感感染的危险因素，但却是SARS-CoV-2的保护因素（OR=2.62;IC95％：1.66-4.13;OR=0.65;IC95％：0.45-0.94），分别。此外，我们的研究结果揭示了流动性与流感感染率之间的直接相关性(0.214;p<0.001).
■该研究提供了在社会重新激活期间呼吸道病毒重新出现和流行的证据，促进未来的预防措施。
