UNASSIGNED: We sought to evaluate the prevalence, risk associations, and sex differences in elevated pulmonary pressures in the largest cohort of patients with ApHCM at a single tertiary center. A total of 542 patients diagnosed with ApHCM were identified using ICD codes and clinical notes searches, confirmed by cross-referencing with cardiac MRI reports extracted through Natural Language Processing and through manual evaluation of patient charts and imaging records.
UNASSIGNED: In 414 patients, echocardiogram measurements of pulmonary artery systolic pressure (PASP) were obtained at the time of diagnosis. The mean age was 59.4 ± 16.6 years, with 181 (44%) being females. The mean PASP was 38 ± 12 mmHg in females vs. 33 ± 9 mmHg in males (p < 0.0001). PH as defined by a PASP value of > 36 mmHg was present in 140/414 (34%) patients, with a predominance in females [79/181 (44%)] vs. males [61/233 (26%), p < 0.0001]. Female sex, atrial fibrillation, diagnosis of congestive heart failure, and elevated filling pressures on echocardiogram remained significantly associated with PH (PASP > 36 mmHg) in multivariable modeling. PH, when present, was independently associated with mortality [hazard ratio 1.63, 95% CI (1.05-2.53), p = 0.028] and symptoms [odds ratio 2.28 (1.40, 3.71), p < 0.001].
UNASSIGNED: PH was present in 34% of patients with ApHCM at diagnosis, with female sex predominance. PH in ApHCM was associated with symptoms and increased mortality.
■我们试图评估患病率,风险关联,单三级中心最大的ApHCM患者队列中肺压升高的性别差异。使用ICD代码和临床笔记搜索确定了总共542名诊断为ApHCM的患者。通过与通过自然语言处理提取的心脏MRI报告的交叉引用以及通过手动评估患者图表和成像记录来确认。
■在414名患者中,在诊断时获得肺动脉收缩压(PASP)的超声心动图测量值。平均年龄59.4±16.6岁,181人(44%)为女性。女性与女性的平均PASP为38±12mmHg。男性为33±9mmHg(p<0.0001)。由PASP值>36mmHg定义的PH在140/414(34%)患者中存在,以女性为主[79/181(44%)]与男性[61/233(26%),p<0.0001]。女性性别,心房颤动,充血性心力衰竭的诊断,在多变量模型中,超声心动图上的充盈压升高与PH(PASP>36mmHg)显著相关。PH,当存在时,与死亡率独立相关[风险比1.63,95%CI(1.05-2.53),p=0.028]和症状[赔率比2.28(1.40,3.71),p<0.001]。
■34%的ApHCM患者在诊断时存在PH,女性占主导地位。ApHCM中的PH与症状和死亡率增加有关。