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Abstract：
BACKGROUND: Previous studies have shown that children with intermittent exotropia (IXT) have a higher rate of psychiatric abnormalities as they grow up, such as attention deficit. This study explored visual and hearing attention among children with IXT, and evaluated its association with clinical characteristics and cognitive development.
METHODS: Forty-nine children with a diagnosis of IXT and 29 children with traditional development were recruited. The Integrated Visual and Auditory Continuous Performance Test (IVA-CPT) was used to measure the subjects\' full-scale response control quotient (FSRCQ), full-scale attention quotient (FSAQ), auditory response control quotient (ARCQ), auditory attention quotient (AAQ), visual response control quotient (VRCQ), and visual attention quotient (VAQ). The Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) was used to assess their cognitive function. The differences between the scores of children with IXT and normal controls were analyzed.
RESULTS: The results showed that the FSRCQ, FSAQ, ARCQ, AAQ, VRCQ, and VAQ of children with IXT were all lower than those of normal controls with the same age (P < 0.05). The level of attention was significantly correlated with the age of strabismus onset (P < 0.05), but not with the degree of strabismus, stereopsis, or fusion control score. In addition, audiovisual attention was correlated significantly with their cognitive development level. The random forest classifier prediction model showed that age of strabismus onset was an important predictor of attention.
CONCLUSIONS: Children with IXT have lower visual and auditory attention and control than their peers, and the age of onset of strabismus may be a major factor.
METHODS: Forty-nine children with a diagnosis of IXT and 29 children with traditional development were recruited. The Integrated Visual and Auditory Continuous Performance Test (IVA-CPT) was used to measure the subjects\' full-scale response control quotient (FSRCQ), full-scale attention quotient (FSAQ), auditory response control quotient (ARCQ), auditory attention quotient (AAQ), visual response control quotient (VRCQ), and visual attention quotient (VAQ). The Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV) was used to assess their cognitive function. The differences between the scores of children with IXT and normal controls were analyzed.
RESULTS: The results showed that the FSRCQ, FSAQ, ARCQ, AAQ, VRCQ, and VAQ of children with IXT were all lower than those of normal controls with the same age (P < 0.05). The level of attention was significantly correlated with the age of strabismus onset (P < 0.05), but not with the degree of strabismus, stereopsis, or fusion control score. In addition, audiovisual attention was correlated significantly with their cognitive development level. The random forest classifier prediction model showed that age of strabismus onset was an important predictor of attention.
CONCLUSIONS: Children with IXT have lower visual and auditory attention and control than their peers, and the age of onset of strabismus may be a major factor.
摘要：
背景：先前的研究表明，间歇性外斜视（IXT）的儿童在成长过程中出现精神病的比率更高，比如注意力不足。这项研究探讨了IXT儿童的视觉和听觉注意力，并评估其与临床特征和认知发育的关系。
方法：招募49名诊断为IXT的儿童和29名传统发育儿童。综合视觉和听觉连续表现测试（IVA-CPT）用于测量受试者的全面反应控制商（FSRCQ），全面注意力商(FSAQ)，听觉反应控制商（ARCQ），听觉注意商（AAQ），视觉响应控制商(VRCQ)，和视觉注意商(VAQ)。采用韦氏儿童智力量表第四版(WISC-IV)评估其认知功能。分析IXT患儿与正常对照组评分的差异。
结果：结果表明，FSRCQ，FSAQ,ARCQ,AAQ,VRCQ,IXT患儿的VAQ均低于正常对照组(P<0.05)。注意水平与斜视发病年龄显著相关(P<0.05),但没有斜视的程度，立体视觉，或融合控制评分。此外,视听注意与认知发展水平显著相关。随机森林分类器预测模型表明斜视发作年龄是注意力的重要预测因子。
结论：IXT儿童的视觉和听觉注意力和控制力低于同龄人，斜视的发病年龄可能是一个主要因素。
方法：招募49名诊断为IXT的儿童和29名传统发育儿童。综合视觉和听觉连续表现测试（IVA-CPT）用于测量受试者的全面反应控制商（FSRCQ），全面注意力商(FSAQ)，听觉反应控制商（ARCQ），听觉注意商（AAQ），视觉响应控制商(VRCQ)，和视觉注意商(VAQ)。采用韦氏儿童智力量表第四版(WISC-IV)评估其认知功能。分析IXT患儿与正常对照组评分的差异。
结果：结果表明，FSRCQ，FSAQ,ARCQ,AAQ,VRCQ,IXT患儿的VAQ均低于正常对照组(P<0.05)。注意水平与斜视发病年龄显著相关(P<0.05),但没有斜视的程度，立体视觉，或融合控制评分。此外,视听注意与认知发展水平显著相关。随机森林分类器预测模型表明斜视发作年龄是注意力的重要预测因子。
结论：IXT儿童的视觉和听觉注意力和控制力低于同龄人，斜视的发病年龄可能是一个主要因素。
