PDF(Pubmed)
Abstract：
Accumulating evidence indicates that exosomes help to regulate bone homeostasis. The roles of bone-derived exosomes have been well-described; however, recent studies have shown that some non-bone-derived exosomes have better bone targeting ability than bone-derived exosomes and that their performance as a drug delivery vehicle for regulating bone homeostasis may be better than that of bone-derived exosomes, and the sources of non-bone-derived exosomes are more extensive and can thus be better for clinical needs. Here, we sort non-bone-derived exosomes and describe their composition and biogenesis. Their roles and specific mechanisms in bone homeostasis and bone-related diseases are also discussed. Furthermore, we reveal obstacles to current research and future challenges in the practical application of exosomes, and we provide potential strategies for more effective application of exosomes for the regulation of bone homeostasis and the treatment of bone-related diseases. Video Abstract.
摘要：
越来越多的证据表明外泌体有助于调节骨稳态。骨源性外泌体的作用已经被很好地描述;然而，最近的研究表明，一些非骨来源的外泌体比骨来源的外泌体具有更好的骨靶向能力，它们作为调节骨稳态的药物递送载体的性能可能比骨来源的外泌体更好。非骨来源的外泌体来源更广泛，因此可以更好地满足临床需求。这里,我们对非骨来源的外泌体进行排序，并描述它们的组成和生物发生。还讨论了它们在骨稳态和骨相关疾病中的作用和具体机制。此外，我们揭示了外来体实际应用中当前研究的障碍和未来的挑战，我们为更有效地应用外泌体调节骨稳态和治疗骨相关疾病提供了潜在的策略。视频摘要。
