METHODS: 240 individuals (AD = 120, healthy controls = 120) completed an at-home assessment of their short-term resting vagally-mediated HRV using a wristband, monitored over videoconference. Following quality control, analyses were performed investigating differences in HRV between individuals with AD (n = 119) and healthy controls (n = 116), associations of HRV with anxiety-related traits and confounders, and antidepressants effects on HRV in patients, including analyses stratified by ancestry (i.e., European, East Asian, African).
RESULTS: Among the confounders investigated, only age had a significant association with HRV. Patients with an AD had significantly lower vagally-mediated HRV than healthy controls in the European subsample, with a trend of significance in the whole sample. HRV was significantly associated with the Hamilton Anxiety Rating Scale (HAM-A) but not with antidepressant use in the European subsample.
CONCLUSIONS: The study measures occurred in a non-standardized at-home setting, and the three ancestry group sample sizes were unequal.
CONCLUSIONS: This study demonstrates reduced vagally-mediated HRV among patients with ADs compared to healthy controls. Results also point to low HRV being related to more physical anxiety symptoms (measured via HAM-A), suggesting a possible anxiety subtype. Overall, this study highlights the feasibility of using wearables for patients and encourages exploration of the biological and clinical utility of HRV as a risk factor for ADs.
方法:240名个体(AD=120,健康对照=120)使用腕带在家中完成了对其短期静息性迷走神经介导的HRV的评估,通过视频会议监控。在质量控制之后,进行了分析,调查了AD患者(n=119)和健康对照(n=116)之间的HRV差异,HRV与焦虑相关特征和混杂因素的关联,和抗抑郁药对患者HRV的影响,包括按祖先分层的分析(即,欧洲,东亚,African).
结果:在调查的混杂因素中,只有年龄与HRV有显著关联.在欧洲子样本中,AD患者的迷走神经介导的HRV明显低于健康对照,在整个样本中具有重要的趋势。在欧洲子样本中,HRV与汉密尔顿焦虑量表(HAM-A)显着相关,但与抗抑郁药的使用无关。
结论:研究措施发生在非标准化的家庭环境中,三个祖先组样本量不相等。
结论:这项研究表明,与健康对照组相比,AD患者的迷走神经介导的HRV降低。结果还指出,低HRV与更多的身体焦虑症状有关(通过HAM-A测量),提示一种可能的焦虑亚型.总的来说,这项研究强调了患者使用可穿戴设备的可行性,并鼓励探索HRV作为AD的危险因素的生物学和临床实用性.