Abstract：
BACKGROUND: Reduced vagally-mediated heart rate variability (HRV) has been associated with anxiety disorders (AD). The aim of this study was to use a wearable device and remote study design to re-evaluate the association of HRV with ADs, anxiety-related traits, and confounders.
METHODS: 240 individuals (AD = 120, healthy controls = 120) completed an at-home assessment of their short-term resting vagally-mediated HRV using a wristband, monitored over videoconference. Following quality control, analyses were performed investigating differences in HRV between individuals with AD (n = 119) and healthy controls (n = 116), associations of HRV with anxiety-related traits and confounders, and antidepressants effects on HRV in patients, including analyses stratified by ancestry (i.e., European, East Asian, African).
RESULTS: Among the confounders investigated, only age had a significant association with HRV. Patients with an AD had significantly lower vagally-mediated HRV than healthy controls in the European subsample, with a trend of significance in the whole sample. HRV was significantly associated with the Hamilton Anxiety Rating Scale (HAM-A) but not with antidepressant use in the European subsample.
CONCLUSIONS: The study measures occurred in a non-standardized at-home setting, and the three ancestry group sample sizes were unequal.
CONCLUSIONS: This study demonstrates reduced vagally-mediated HRV among patients with ADs compared to healthy controls. Results also point to low HRV being related to more physical anxiety symptoms (measured via HAM-A), suggesting a possible anxiety subtype. Overall, this study highlights the feasibility of using wearables for patients and encourages exploration of the biological and clinical utility of HRV as a risk factor for ADs.
METHODS: 240 individuals (AD = 120, healthy controls = 120) completed an at-home assessment of their short-term resting vagally-mediated HRV using a wristband, monitored over videoconference. Following quality control, analyses were performed investigating differences in HRV between individuals with AD (n = 119) and healthy controls (n = 116), associations of HRV with anxiety-related traits and confounders, and antidepressants effects on HRV in patients, including analyses stratified by ancestry (i.e., European, East Asian, African).
RESULTS: Among the confounders investigated, only age had a significant association with HRV. Patients with an AD had significantly lower vagally-mediated HRV than healthy controls in the European subsample, with a trend of significance in the whole sample. HRV was significantly associated with the Hamilton Anxiety Rating Scale (HAM-A) but not with antidepressant use in the European subsample.
CONCLUSIONS: The study measures occurred in a non-standardized at-home setting, and the three ancestry group sample sizes were unequal.
CONCLUSIONS: This study demonstrates reduced vagally-mediated HRV among patients with ADs compared to healthy controls. Results also point to low HRV being related to more physical anxiety symptoms (measured via HAM-A), suggesting a possible anxiety subtype. Overall, this study highlights the feasibility of using wearables for patients and encourages exploration of the biological and clinical utility of HRV as a risk factor for ADs.
摘要：
背景：迷走神经介导的心率变异性（HRV）降低与焦虑症（AD）相关。本研究的目的是使用可穿戴设备和远程研究设计来重新评估HRV与AD的关联，焦虑相关特征，和混杂因素。
方法：240名个体（AD=120，健康对照=120）使用腕带在家中完成了对其短期静息性迷走神经介导的HRV的评估，通过视频会议监控。在质量控制之后，进行了分析，调查了AD患者（n=119）和健康对照（n=116）之间的HRV差异，HRV与焦虑相关特征和混杂因素的关联，和抗抑郁药对患者HRV的影响，包括按祖先分层的分析(即，欧洲,东亚,African).
结果：在调查的混杂因素中，只有年龄与HRV有显著关联.在欧洲子样本中，AD患者的迷走神经介导的HRV明显低于健康对照，在整个样本中具有重要的趋势。在欧洲子样本中，HRV与汉密尔顿焦虑量表（HAM-A）显着相关，但与抗抑郁药的使用无关。
结论：研究措施发生在非标准化的家庭环境中，三个祖先组样本量不相等。
结论：这项研究表明，与健康对照组相比，AD患者的迷走神经介导的HRV降低。结果还指出，低HRV与更多的身体焦虑症状有关（通过HAM-A测量），提示一种可能的焦虑亚型.总的来说,这项研究强调了患者使用可穿戴设备的可行性,并鼓励探索HRV作为AD的危险因素的生物学和临床实用性.
方法：240名个体（AD=120，健康对照=120）使用腕带在家中完成了对其短期静息性迷走神经介导的HRV的评估，通过视频会议监控。在质量控制之后，进行了分析，调查了AD患者（n=119）和健康对照（n=116）之间的HRV差异，HRV与焦虑相关特征和混杂因素的关联，和抗抑郁药对患者HRV的影响，包括按祖先分层的分析(即，欧洲,东亚,African).
结果：在调查的混杂因素中，只有年龄与HRV有显著关联.在欧洲子样本中，AD患者的迷走神经介导的HRV明显低于健康对照，在整个样本中具有重要的趋势。在欧洲子样本中，HRV与汉密尔顿焦虑量表（HAM-A）显着相关，但与抗抑郁药的使用无关。
结论：研究措施发生在非标准化的家庭环境中，三个祖先组样本量不相等。
结论：这项研究表明，与健康对照组相比，AD患者的迷走神经介导的HRV降低。结果还指出，低HRV与更多的身体焦虑症状有关（通过HAM-A测量），提示一种可能的焦虑亚型.总的来说,这项研究强调了患者使用可穿戴设备的可行性,并鼓励探索HRV作为AD的危险因素的生物学和临床实用性.
