影响 NQO1 蛋白水平的遗传变异影响艾地苯醌治疗 Leber 遗传性视神经病变的疗效.
关键词: LHON Leber hereditary optic neuropathy NQO1 complex I cybrids fibroblasts idebenone mtDNA retinal ganglion cells
Mesh : Humans Optic Atrophy, Hereditary, Leber / drug therapy genetics metabolism Antioxidants / therapeutic use pharmacology Retrospective Studies Ubiquinone / pharmacology therapeutic use metabolism analogs & derivatives Electron Transport Complex I / genetics NAD(P)H Dehydrogenase (Quinone) / genetics metabolism
来 源:
DOI:10.1016/j.xcrm.2023.101383
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