Abstract：
Implantable chemical sensors built with flexible and biodegradable materials exhibit immense potential for seamless integration with biological systems by matching the mechanical properties of soft tissues and eliminating device retraction procedures. Compared with conventional hospital-based blood tests, implantable chemical sensors have the capability to achieve real-time monitoring with high accuracy of important biomarkers such as metabolites, neurotransmitters, and proteins, offering valuable insights for clinical applications. These innovative sensors could provide essential information for preventive diagnosis and effective intervention. To date, despite extensive research on flexible and bioresorbable materials for implantable electronics, the development of chemical sensors has faced several challenges related to materials and device design, resulting in only a limited number of successful accomplishments. This review highlights recent advancements in implantable chemical sensors based on flexible and biodegradable materials, encompassing their sensing strategies, materials strategies, and geometric configurations. The following discussions focus on demonstrated detection of various objects including ions, small molecules, and a few examples of macromolecules using flexible and/or bioresorbable implantable chemical sensors. Finally, we will present current challenges and explore potential future directions.
摘要：
采用柔性和可生物降解材料构建的植入式化学传感器通过匹配软组织的机械性能和消除设备回缩程序，具有与生物系统无缝集成的巨大潜力。与传统的医院血液检查相比，植入式化学传感器能够实现对代谢物等重要生物标志物的高精度实时监测，神经递质,和蛋白质，为临床应用提供有价值的见解。这些创新的传感器可以为预防性诊断和有效干预提供必要的信息。迄今为止,尽管对可植入电子设备的柔性和生物可吸收材料进行了广泛的研究，化学传感器的发展面临着与材料和器件设计相关的几个挑战，只有有限的成功成就。这篇综述强调了基于柔性和可生物降解材料的可植入化学传感器的最新进展。包括他们的感知策略，材料战略，和几何构型。以下讨论集中在演示的各种物体的检测，包括离子，小分子,以及使用柔性和/或生物可吸收的可植入化学传感器的大分子的一些实例。最后,我们将提出当前的挑战，并探索潜在的未来方向。
