RESULTS: Analyses revealed overlapping between decreased regional rCBF and 18F-FDG PET SUVR in patients with AD compared with NC participants in the bilateral parietotemporal regions, frontal cortex, and cingulate cortex. Compared with NC participants, patients with aMCI exclusively demonstrated lower 18F-FDG PET SUVR in the bilateral temporal cortex, insula cortex, and inferior frontal cortex. Comparison of the rCBF in patients with aMCI and NC participants revealed no significant difference (P > 0.05). The ROC analysis of rCBF in the meta-ROI could diagnose patients with AD (AUC, 0.87) but not aMCI (AUC, 0.61). The specificity of diagnosing aMCI has been improved to 75.56% when combining rCBF and 18F-FDG PET SUVR.
CONCLUSIONS: ASL could detect similar aberrant patterns of abnormalities compared to 18F-FDG PET in patients with AD compared with NC participants but not in aMCI. The diagnostic efficiency of 18F-FDG-PET for AD and aMCI patients remained higher to ASL. Our findings support that applying 18F-FDG PET may be preferable for diagnosing AD and aMCI.
结果:分析显示,与双侧顶颞区的NC参与者相比,AD患者中降低的区域rCBF和18F-FDGPETSUVR重叠,额叶皮质,和扣带皮质.与NC参与者相比,aMCI患者仅在双侧颞叶皮质表现出较低的18F-FDGPETSUVR,脑岛皮层,和下额叶皮层.aMCI患者和NC患者的rCBF比较差异无统计学意义(P>0.05)。meta-ROI中rCBF的ROC分析可以诊断AD患者(AUC,0.87),但不是aMCI(AUC,0.61)。结合rCBF和18F-FDGPETSUVR诊断aMCI的特异性提高到75.56%。
结论:与18F-FDGPET相比,在AD患者中,与NC参与者相比,ASL可以检测到类似的异常异常模式,但在aMCI中没有。18F-FDG-PET对AD和aMCI患者的诊断效率仍然高于ASL。我们的发现支持应用18F-FDGPET可能更适合诊断AD和aMCI。