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Abstract：
BACKGROUND: Postherpetic neuralgia (PHN) causes severe pain which can lead to decreased quality-of-life. This study aimed to evaluate the effects of inhalation of lavender (Lavandula angustifolia) oil and its major components (linalool and linalyl acetate) on the pain in patients with PHN.
METHODS: This study was performed at an outpatient clinic. Sixty-four patients with postherpetic neuralgia were randomly allocated to a control group (almond oil) or one of three experimental groups (lavender oil, linalool, or linalyl acetate diluted in almond oil at concentration of 1% v/v), and the participants inhaled the aroma by natural breathing. Quality, severity, and intensity of pain were measured before and after the intervention.
RESULTS: Six patients discontinued the intervention for personal reasons; hence, data from 58 patients were analyzed (control group, n = 14; 1% lavender oil group, n = 15; 1% linalool, n = 15; 1% linalyl acetate, n = 14). Reduction in sensory pain was greater in the 1% lavender oil group, 1% linalool group, and 1% linalyl acetate group than in the control group (all P < 0.001). Reduction in affective pain was greater in the 1% lavender group (P < 0.001) and the 1% linalool group (P = 0.007) than in the control group. Decreases in pain severity and intensity were significantly greater in all three intervention groups than in the control group.
CONCLUSIONS: Inhalation of lavender oil and its major volatile components effectively reduced the quality, severity, and intensity of postherpetic pain, suggesting that lavender oil, linalool, and linalyl acetate may each be an effective intervention for reducing pain in patients with postherpetic neuralgia.
BACKGROUND: This study was retrospectively registered on the Clinical Research Information Service.
BACKGROUND: KCT0007772, first registration 06/10/2022.
METHODS: This study was performed at an outpatient clinic. Sixty-four patients with postherpetic neuralgia were randomly allocated to a control group (almond oil) or one of three experimental groups (lavender oil, linalool, or linalyl acetate diluted in almond oil at concentration of 1% v/v), and the participants inhaled the aroma by natural breathing. Quality, severity, and intensity of pain were measured before and after the intervention.
RESULTS: Six patients discontinued the intervention for personal reasons; hence, data from 58 patients were analyzed (control group, n = 14; 1% lavender oil group, n = 15; 1% linalool, n = 15; 1% linalyl acetate, n = 14). Reduction in sensory pain was greater in the 1% lavender oil group, 1% linalool group, and 1% linalyl acetate group than in the control group (all P < 0.001). Reduction in affective pain was greater in the 1% lavender group (P < 0.001) and the 1% linalool group (P = 0.007) than in the control group. Decreases in pain severity and intensity were significantly greater in all three intervention groups than in the control group.
CONCLUSIONS: Inhalation of lavender oil and its major volatile components effectively reduced the quality, severity, and intensity of postherpetic pain, suggesting that lavender oil, linalool, and linalyl acetate may each be an effective intervention for reducing pain in patients with postherpetic neuralgia.
BACKGROUND: This study was retrospectively registered on the Clinical Research Information Service.
BACKGROUND: KCT0007772, first registration 06/10/2022.
摘要：
背景：带状疱疹后遗神经痛（PHN）引起严重疼痛，可导致生活质量下降。本研究旨在评估吸入薰衣草（Lavandulaangustifolia）油及其主要成分（芳樟醇和醋酸芳酯）对PHN患者疼痛的影响。
方法：本研究在门诊进行。将64例带状疱疹后遗神经痛患者随机分为对照组（杏仁油）或三个实验组（薰衣草油，芳樟醇,或在浓度为1％v/v的杏仁油中稀释的醋酸酯），参与者通过自然呼吸吸入香气。质量,严重程度,在干预前后测量疼痛强度。
结果：6名患者因个人原因停止干预；因此，对58例患者的数据进行了分析(对照组，n=14；1%薰衣草油组，n=15；1%芳樟醇，n=15；1%醋酸亚油酸酯，n=14)。1％薰衣草油组的感觉疼痛减轻更大，1%芳樟醇组，和1%醋酸酯组高于对照组(均P<0.001)。1％薰衣草组（P<0.001）和1％芳樟醇组（P=0.007）的情感性疼痛减轻程度高于对照组。所有三个干预组的疼痛严重程度和强度的下降均明显大于对照组。
结论：吸入薰衣草油及其主要挥发性成分可有效降低其质量，严重程度,和带状疱疹后疼痛的强度，暗示薰衣草油，芳樟醇,和醋酸酯均可能是减轻带状疱疹后神经痛患者疼痛的有效干预措施。
背景：本研究在临床研究信息服务处进行了回顾性注册。
背景：KCT0007772，首次注册06/10/2022。
方法：本研究在门诊进行。将64例带状疱疹后遗神经痛患者随机分为对照组（杏仁油）或三个实验组（薰衣草油，芳樟醇,或在浓度为1％v/v的杏仁油中稀释的醋酸酯），参与者通过自然呼吸吸入香气。质量,严重程度,在干预前后测量疼痛强度。
结果：6名患者因个人原因停止干预；因此，对58例患者的数据进行了分析(对照组，n=14；1%薰衣草油组，n=15；1%芳樟醇，n=15；1%醋酸亚油酸酯，n=14)。1％薰衣草油组的感觉疼痛减轻更大，1%芳樟醇组，和1%醋酸酯组高于对照组(均P<0.001)。1％薰衣草组（P<0.001）和1％芳樟醇组（P=0.007）的情感性疼痛减轻程度高于对照组。所有三个干预组的疼痛严重程度和强度的下降均明显大于对照组。
结论：吸入薰衣草油及其主要挥发性成分可有效降低其质量，严重程度,和带状疱疹后疼痛的强度，暗示薰衣草油，芳樟醇,和醋酸酯均可能是减轻带状疱疹后神经痛患者疼痛的有效干预措施。
背景：本研究在临床研究信息服务处进行了回顾性注册。
背景：KCT0007772，首次注册06/10/2022。
