Abstract：
BACKGROUND: With advances in medical care and assisted reproductive technologies (ART), fertility prospects for prune-belly syndrome (PBS) men may be changing. This review aims to identify the factors influencing fertility and optimization of reproductive health for PBS patients.
METHODS: A scoping review was performed on all records published over 70 years (1952-2022) analyzing fertility in PBS males. Records were summarized in a table and narrative describing cryptorchidism, orchiopexy, testicle histology; prostate characteristics; sex hormone function; semen analyses, ART, and conception ability. This review was registered on Open Science Framework (OSF) and conducted using PRISMA methodology.
RESULTS: 827 articles were identified and 83 were selected for data extraction. Before 2000, there were 0.85 publications/year whereas after 2000 there were 1.95 publications/year. Orchiopexy successfully relocated 86 % of PBS testicles into the scrotum. Testicular histology demonstrated 50 % of patients had no spermatogonia, while 47.2 % and 2.7 % had reduced or normal numbers respectively. Leydig hyperplasia and Sertoli only histology were found in 19.4 % of patients. Prostatic hypoplasia and prostatic urethral dilation were found in 93.6 % and 91.4 % of patients respectively. Testosterone, Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) were normal in 93.9 %, 87.7 % and 77.9 % of patients respectively. Azoospermia and oligospermia was found in 75.7 % and 21.6 % of patients respectively while 60.7 % had antegrade ejaculation. ART successfully extracted sperm in 6 instances and resulted in 4 conceptions, while natural conception was reported twice.
CONCLUSIONS: Data analysis indicates increased attention to fertility prospects for PBS males with evaluation of PBS patient\'s hormonal function, semen analyses, ART, and conception ability. The reviewed data suggest that PBS males may father biological offspring with contemporary management and also demonstrate the need for consistent reproductive management approaches to maximize their fertility prospects.
METHODS: A scoping review was performed on all records published over 70 years (1952-2022) analyzing fertility in PBS males. Records were summarized in a table and narrative describing cryptorchidism, orchiopexy, testicle histology; prostate characteristics; sex hormone function; semen analyses, ART, and conception ability. This review was registered on Open Science Framework (OSF) and conducted using PRISMA methodology.
RESULTS: 827 articles were identified and 83 were selected for data extraction. Before 2000, there were 0.85 publications/year whereas after 2000 there were 1.95 publications/year. Orchiopexy successfully relocated 86 % of PBS testicles into the scrotum. Testicular histology demonstrated 50 % of patients had no spermatogonia, while 47.2 % and 2.7 % had reduced or normal numbers respectively. Leydig hyperplasia and Sertoli only histology were found in 19.4 % of patients. Prostatic hypoplasia and prostatic urethral dilation were found in 93.6 % and 91.4 % of patients respectively. Testosterone, Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH) were normal in 93.9 %, 87.7 % and 77.9 % of patients respectively. Azoospermia and oligospermia was found in 75.7 % and 21.6 % of patients respectively while 60.7 % had antegrade ejaculation. ART successfully extracted sperm in 6 instances and resulted in 4 conceptions, while natural conception was reported twice.
CONCLUSIONS: Data analysis indicates increased attention to fertility prospects for PBS males with evaluation of PBS patient\'s hormonal function, semen analyses, ART, and conception ability. The reviewed data suggest that PBS males may father biological offspring with contemporary management and also demonstrate the need for consistent reproductive management approaches to maximize their fertility prospects.
摘要：
背景：随着医疗保健和辅助生殖技术（ART）的进步，修剪型腹部综合征（PBS）男性的生育前景可能正在发生变化。本文旨在确定影响PBS患者生育和生殖健康优化的因素。
方法：对70年（1952-2022年）发表的所有记录进行了范围审查，分析了PBS男性的生育力。记录总结在一张表格和描述隐睾的叙述中，诊所,睾丸组织学;前列腺特征;性激素功能;精液分析,ART,和概念能力。这篇综述在开放科学框架(OSF)上注册，并使用PRISMA方法进行。
结果：确定了827篇文章，选择了83篇文章进行数据提取。在2000年之前，每年有0.85份出版物，而在2000年之后，每年有1.95份出版物。睾丸固定术成功地将86％的PBS睾丸重新定位到阴囊中。睾丸组织学显示50%的患者没有精原细胞，而47.2%和2.7%的数字分别减少或正常。在19.4％的患者中发现了Leydig增生和Sertoli仅组织学。前列腺发育不全和前列腺尿道扩张分别占93.6%和91.4%。睾酮,促黄体生成素(LH)和促卵泡激素(FSH)正常占93.9%,分别为87.7%和77.9%的患者。无精子症和少精子症分别在75.7%和21.6%的患者中发现，而60.7%的患者出现顺行射精。ART在6个实例中成功提取了精子，并产生了4个概念，而自然受孕被报道两次。
结论：数据分析表明，通过评估PBS患者的激素功能，对PBS男性的生育前景越来越关注，精液分析,ART,和概念能力。审查的数据表明，PBS雄性可能会通过当代管理来生育后代，并且还表明需要一致的生殖管理方法来最大程度地提高其生育前景。
方法：对70年（1952-2022年）发表的所有记录进行了范围审查，分析了PBS男性的生育力。记录总结在一张表格和描述隐睾的叙述中，诊所,睾丸组织学;前列腺特征;性激素功能;精液分析,ART,和概念能力。这篇综述在开放科学框架(OSF)上注册，并使用PRISMA方法进行。
结果：确定了827篇文章，选择了83篇文章进行数据提取。在2000年之前，每年有0.85份出版物，而在2000年之后，每年有1.95份出版物。睾丸固定术成功地将86％的PBS睾丸重新定位到阴囊中。睾丸组织学显示50%的患者没有精原细胞，而47.2%和2.7%的数字分别减少或正常。在19.4％的患者中发现了Leydig增生和Sertoli仅组织学。前列腺发育不全和前列腺尿道扩张分别占93.6%和91.4%。睾酮,促黄体生成素(LH)和促卵泡激素(FSH)正常占93.9%,分别为87.7%和77.9%的患者。无精子症和少精子症分别在75.7%和21.6%的患者中发现，而60.7%的患者出现顺行射精。ART在6个实例中成功提取了精子，并产生了4个概念，而自然受孕被报道两次。
结论：数据分析表明，通过评估PBS患者的激素功能，对PBS男性的生育前景越来越关注，精液分析,ART,和概念能力。审查的数据表明，PBS雄性可能会通过当代管理来生育后代，并且还表明需要一致的生殖管理方法来最大程度地提高其生育前景。
