Abstract：
In this work, a colorimetric/fluorescent dual-signal mode sensor is proposed for the sensitive, selective and accurate detection and removal of tetracycline antibiotics (TCs). A triple-metal MOF of NiCoFe is successfully synthesized and controllable adjusted the shape of the hollow structure for the first time, and then modified with TCs aptamer. The as-prepared triple-atom MOF (apt-NiCoFe-MOF-74) exhibits well-defined hollow morphology, high crystallinity, and high surface areas endow their alluring adsorption and removal performances for TCs. More attractively, this triple-metal MOF show a good peroxidase-like activity and strong fluorescence property at 540 nm of apt-NiCoFe-MOF-74 when excitation wavelength was 370 nm. Inspire by this, a dual-signal output biosensor is constructed and the linear absorbance response is well correlated with wide range and low LOD for TCs. The biosensor provided an universal method with satisfactory sensitivity and accuracy for TCs analysis in real food samples.
摘要：
在这项工作中,提出了一种比色/荧光双信号模式传感器，选择性和准确的检测和去除四环素类抗生素（TCs）。首次成功合成了NiCoFe的三金属MOF，并对中空结构的形状进行了可控调整，然后用TCs适体修饰。制备的三原子MOF（apt-NiCoFe-MOF-74）表现出明确的中空形态，结晶度高，和高表面积赋予了它们对TC的诱人吸附和去除性能。更吸引人的是,当激发波长为370nm时，该三金属MOF在540nm处表现出apt-NiCoFe-MOF-74良好的过氧化物酶样活性和强荧光性质。受此启发，构建了双信号输出生物传感器，线性吸光度响应与TC的宽范围和低LOD密切相关。该生物传感器为实际食品样品中的TC分析提供了一种具有令人满意的灵敏度和准确性的通用方法。
