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Abstract：
BACKGROUND: Epidermoid cysts, originating from ectodermal cell remnants during embryogenesis, are rare, slow-growing tumours commonly found in the cerebellopontine angle, fourth ventricle, and sellar/parasellar regions. This retrospective study explores clinicopathological features, demographics, and radiological details of fifteen central nervous system epidermoid cyst cases over three years.
METHODS: Histologically confirmed cases undergoing surgical excision from July 2020 to July 2023 were retrospectively evaluated. Patient age, clinical presentations, radiological features, and histopathological findings were analyzed using descriptive statistics and aligned with the PROCESS criteria.
RESULTS: Fifteen cases, spanning various age groups and clinical presentations, were included. There were four cases each in the posterior fossa and cerebellopontine angle, three in temporal region, two in intraspinal region, and one each in the retromastoid intra-diploic and third intra-ventricular region. Lesions exhibited diverse distribution, gross findings, and microscopic features. Radiological imaging exhibited well-defined hypo-attenuated masses on computed tomography and contributed to the preoperative diagnosis in eight cases. Despite challenges in complete excision due to adherence, 13 cases underwent successful resection. Chemical meningitis, a common postoperative complication, underscores the importance of meticulous surgery.
CONCLUSIONS: This study highlights clinicopathological characteristics, challenges in surgical management, and postoperative complications of central nervous system epidermoid cysts. Comparative analysis with existing literature emphasizes the uniqueness of epidermoid cysts, differentiating them from craniopharyngiomas and dermoid cysts. Despite the retrospective design, valuable insights are provided, emphasizing the need for prospective studies. Effective management involves complete excision, ensuring long-term remission and emphasizing the distinctive nature of these intriguing intracranial lesions.
METHODS: Histologically confirmed cases undergoing surgical excision from July 2020 to July 2023 were retrospectively evaluated. Patient age, clinical presentations, radiological features, and histopathological findings were analyzed using descriptive statistics and aligned with the PROCESS criteria.
RESULTS: Fifteen cases, spanning various age groups and clinical presentations, were included. There were four cases each in the posterior fossa and cerebellopontine angle, three in temporal region, two in intraspinal region, and one each in the retromastoid intra-diploic and third intra-ventricular region. Lesions exhibited diverse distribution, gross findings, and microscopic features. Radiological imaging exhibited well-defined hypo-attenuated masses on computed tomography and contributed to the preoperative diagnosis in eight cases. Despite challenges in complete excision due to adherence, 13 cases underwent successful resection. Chemical meningitis, a common postoperative complication, underscores the importance of meticulous surgery.
CONCLUSIONS: This study highlights clinicopathological characteristics, challenges in surgical management, and postoperative complications of central nervous system epidermoid cysts. Comparative analysis with existing literature emphasizes the uniqueness of epidermoid cysts, differentiating them from craniopharyngiomas and dermoid cysts. Despite the retrospective design, valuable insights are provided, emphasizing the need for prospective studies. Effective management involves complete excision, ensuring long-term remission and emphasizing the distinctive nature of these intriguing intracranial lesions.
摘要：
背景：表皮样囊肿，起源于胚胎发育过程中的外胚层细胞残留物，是罕见的，生长缓慢的肿瘤常见于小脑桥脑角，第四脑室,和鞍区/鞍区。这项回顾性研究探讨了临床病理特征，人口统计，以及三年来15例中枢神经系统表皮样囊肿病例的放射学细节。
方法：回顾性评估了2020年7月至2023年7月接受手术切除的组织学确诊病例。患者年龄,临床表现,放射学特征，和组织病理学结果采用描述性统计学方法进行分析,并符合PROCESS标准.
结果：15例，跨越不同的年龄组和临床表现，包括在内。后颅窝和小脑桥脑角各4例，三个在时间区域，两个在脊柱内区域，乳突后二倍体区和第三脑室区各一个。病变表现出不同的分布，粗略的发现，微观特征。放射学成像在计算机断层扫描中显示出清晰的低衰减肿块，并有助于8例患者的术前诊断。尽管由于坚持而在完全切除方面存在挑战，13例成功切除。化学性脑膜炎,常见的术后并发症，强调了细致手术的重要性。
结论：这项研究突出了临床病理特征，外科管理方面的挑战，中枢神经系统表皮样囊肿术后并发症。与现有文献的比较分析强调表皮样囊肿的独特性，将它们与颅咽管瘤和皮样囊肿区分开来。尽管进行了回顾性设计，提供了有价值的见解，强调前瞻性研究的必要性。有效的管理包括完全切除，确保长期缓解，并强调这些有趣的颅内病变的独特性质。
方法：回顾性评估了2020年7月至2023年7月接受手术切除的组织学确诊病例。患者年龄,临床表现,放射学特征，和组织病理学结果采用描述性统计学方法进行分析,并符合PROCESS标准.
结果：15例，跨越不同的年龄组和临床表现，包括在内。后颅窝和小脑桥脑角各4例，三个在时间区域，两个在脊柱内区域，乳突后二倍体区和第三脑室区各一个。病变表现出不同的分布，粗略的发现，微观特征。放射学成像在计算机断层扫描中显示出清晰的低衰减肿块，并有助于8例患者的术前诊断。尽管由于坚持而在完全切除方面存在挑战，13例成功切除。化学性脑膜炎,常见的术后并发症，强调了细致手术的重要性。
结论：这项研究突出了临床病理特征，外科管理方面的挑战，中枢神经系统表皮样囊肿术后并发症。与现有文献的比较分析强调表皮样囊肿的独特性，将它们与颅咽管瘤和皮样囊肿区分开来。尽管进行了回顾性设计，提供了有价值的见解，强调前瞻性研究的必要性。有效的管理包括完全切除，确保长期缓解，并强调这些有趣的颅内病变的独特性质。
