Abstract：
The association between blood glucose and fractures is not consistent across populations. Blood glucose was associated with fractures five years later in middle-aged and elderly men who underwent health examinations in Japan, respectively. Blood glucose-targeted fracture alerts are crucial for middle-aged and elderly individuals.
The evidence on blood glucose as a fracture risk marker has not been adequately examined in various populations, and there are no studies in middle-aged Japanese. We aimed to determine the association between blood glucose status and self-report fractures among middle-aged and elderly Japanese men.
The data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Okazaki Study were used. Hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measured at baseline physical examinations were examined for association with fractures questioned five years later. Analyses were performed for the middle-aged and elderly respondents.
The HbA1c was dichotomized into 290 (11.8%) with HbA1c ≥ 6.5% and 2165 (88.2%) with HbA1c < 6.5%. Compared to the group with an HbA1c < 6.5, the odds ratio for the risks of fracture among the group with an HbA1c ≥ 6.5% were 3.46 (95% confidence interval (CI), 1.75-6.84) in Model 1 (adjusted for age) and 3.60 (95% CI, 1.77-7.34) in Model 2 (adjusted for various confounding factors). These associations were also observed in both middle-aged and elderly generations, whereas no association was observed for FPG.
Among Japanese men who have undergone physical examinations, those with an HbA1c of 6.5% or higher are at higher risk for fractures, and HbA1c-targeted fracture alerts are crucial for middle-aged and elderly individuals.
The evidence on blood glucose as a fracture risk marker has not been adequately examined in various populations, and there are no studies in middle-aged Japanese. We aimed to determine the association between blood glucose status and self-report fractures among middle-aged and elderly Japanese men.
The data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Okazaki Study were used. Hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) measured at baseline physical examinations were examined for association with fractures questioned five years later. Analyses were performed for the middle-aged and elderly respondents.
The HbA1c was dichotomized into 290 (11.8%) with HbA1c ≥ 6.5% and 2165 (88.2%) with HbA1c < 6.5%. Compared to the group with an HbA1c < 6.5, the odds ratio for the risks of fracture among the group with an HbA1c ≥ 6.5% were 3.46 (95% confidence interval (CI), 1.75-6.84) in Model 1 (adjusted for age) and 3.60 (95% CI, 1.77-7.34) in Model 2 (adjusted for various confounding factors). These associations were also observed in both middle-aged and elderly generations, whereas no association was observed for FPG.
Among Japanese men who have undergone physical examinations, those with an HbA1c of 6.5% or higher are at higher risk for fractures, and HbA1c-targeted fracture alerts are crucial for middle-aged and elderly individuals.
摘要：
血糖和骨折之间的关联在人群中并不一致。在日本接受健康检查的中老年男性中，五年后的血糖与骨折有关，分别。针对血糖的骨折警报对中老年人至关重要。
目的：关于血糖作为骨折风险标志物的证据尚未在不同人群中得到充分研究，也没有对中年日本人的研究。我们旨在确定中老年日本男性的血糖状况与自我报告骨折之间的关系。
方法：使用日本多机构协作队列（J-MICC）冈崎研究的数据。基线体检时测量的血红蛋白A1c（HbA1c）和空腹血糖（FPG）与五年后质疑的骨折相关。对中老年受访者进行了分析。
结果：HbA1c分为290（11.8％），HbA1c≥6.5％，HbA1c<6.5％，HbA1c分为2165（88.2％）。与HbA1c<6.5的组相比，HbA1c≥6.5％的组的骨折风险比值比为3.46（95％置信区间（CI），模型1中的1.75-6.84）（经年龄调整）和模型2中的3.60（95％CI，1.77-7.34）（经各种混杂因素调整）。这些关联也在中老年人中观察到，而未观察到FPG的关联。
结论：在接受过体检的日本男性中，HbA1c为6.5%或更高的患者发生骨折的风险更高，针对HbA1c的骨折警报对中老年人至关重要。
目的：关于血糖作为骨折风险标志物的证据尚未在不同人群中得到充分研究，也没有对中年日本人的研究。我们旨在确定中老年日本男性的血糖状况与自我报告骨折之间的关系。
方法：使用日本多机构协作队列（J-MICC）冈崎研究的数据。基线体检时测量的血红蛋白A1c（HbA1c）和空腹血糖（FPG）与五年后质疑的骨折相关。对中老年受访者进行了分析。
结果：HbA1c分为290（11.8％），HbA1c≥6.5％，HbA1c<6.5％，HbA1c分为2165（88.2％）。与HbA1c<6.5的组相比，HbA1c≥6.5％的组的骨折风险比值比为3.46（95％置信区间（CI），模型1中的1.75-6.84）（经年龄调整）和模型2中的3.60（95％CI，1.77-7.34）（经各种混杂因素调整）。这些关联也在中老年人中观察到，而未观察到FPG的关联。
结论：在接受过体检的日本男性中，HbA1c为6.5%或更高的患者发生骨折的风险更高，针对HbA1c的骨折警报对中老年人至关重要。
