PDF(Pubmed)
Abstract：
UNASSIGNED: Antibiotic resistance is an increasing global threat, accelerated by both misuse and overuse of antibiotics. Most antibiotics to humans are prescribed in primary care, commonly for respiratory symptoms, and there is a need for research on the usage of and outcomes after antibiotic treatment to counteract antibiotic resistance.
UNASSIGNED: To evaluate symptom duration, treatment length, and adverse events of antibiotic treatment in children.
UNASSIGNED: Observational study at four out-of-hours services and one paediatric emergency clinic in Norwegian emergency primary care.
UNASSIGNED: 266 children aged 0 to 6 years with fever or respiratory symptoms.
UNASSIGNED: Duration of symptoms and absenteeism from kindergarten/school, treatment length, and reported adverse events.
UNASSIGNED: There were no differences in duration of symptoms, fever or absenteeism when comparing the groups prescribed (30.8%) and not prescribed (69.2%) antibiotics. This lack of difference remained when analysing the subgroup with otitis media.In the group prescribed antibiotics, 84.5% of parents reported giving antibiotics for 5-7 days, and 50.7% reported no difficulties. Adverse events of antibiotics were reported in 42.3% of the cases, the vast majority being gastrointestinal disturbances.
UNASSIGNED: Children with fever or respiratory symptoms experience similar duration of symptoms and absenteeism regardless of antibiotic treatment. A substantial number of parents reported adverse events when the child received antibiotics. Several parents experienced additional difficulties with the treatment, some ending treatment within day 4.
UNASSIGNED: NCT02496559; Results.
Children with fever or respiratory symptoms treated at OOH services experience similar duration of symptoms or absenteeism, regardless of antibiotic treatment.Parents often choose to end antibiotic treatment prematurely due to adverse events, bad taste, or that they find treatment unnecessary.Children often experience adverse events when prescribed antibiotics, mainly gastrointestinal symptoms.
UNASSIGNED: To evaluate symptom duration, treatment length, and adverse events of antibiotic treatment in children.
UNASSIGNED: Observational study at four out-of-hours services and one paediatric emergency clinic in Norwegian emergency primary care.
UNASSIGNED: 266 children aged 0 to 6 years with fever or respiratory symptoms.
UNASSIGNED: Duration of symptoms and absenteeism from kindergarten/school, treatment length, and reported adverse events.
UNASSIGNED: There were no differences in duration of symptoms, fever or absenteeism when comparing the groups prescribed (30.8%) and not prescribed (69.2%) antibiotics. This lack of difference remained when analysing the subgroup with otitis media.In the group prescribed antibiotics, 84.5% of parents reported giving antibiotics for 5-7 days, and 50.7% reported no difficulties. Adverse events of antibiotics were reported in 42.3% of the cases, the vast majority being gastrointestinal disturbances.
UNASSIGNED: Children with fever or respiratory symptoms experience similar duration of symptoms and absenteeism regardless of antibiotic treatment. A substantial number of parents reported adverse events when the child received antibiotics. Several parents experienced additional difficulties with the treatment, some ending treatment within day 4.
UNASSIGNED: NCT02496559; Results.
Children with fever or respiratory symptoms treated at OOH services experience similar duration of symptoms or absenteeism, regardless of antibiotic treatment.Parents often choose to end antibiotic treatment prematurely due to adverse events, bad taste, or that they find treatment unnecessary.Children often experience adverse events when prescribed antibiotics, mainly gastrointestinal symptoms.
摘要：
■抗生素耐药性是一个日益严重的全球威胁，滥用和过度使用抗生素加速了。大多数抗生素是在初级保健中开的，通常是呼吸道症状，并且有必要对抗生素治疗后的使用和结果进行研究，以抵消抗生素耐药性。
■要评估症状持续时间，治疗长度,以及儿童抗生素治疗的不良事件。
■在挪威急诊初级保健的四个非工作时间服务和一个儿科急诊诊所进行的观察性研究。
■266名0至6岁有发热或呼吸道症状的儿童。
■幼儿园/学校的症状和缺勤时间，治疗长度,并报告不良事件。
■症状持续时间没有差异，比较规定（30.8％）和未规定（69.2％）抗生素组的发热或旷工。在分析中耳炎亚组时，这种差异仍然存在。在该组中开了抗生素，84.5%的父母报告给予抗生素5-7天，50.7%报告没有困难。42.3％的病例报告了抗生素的不良事件，绝大多数是胃肠道紊乱。
■有发热或呼吸道症状的儿童无论使用何种抗生素治疗，症状持续时间和缺勤时间相似。当孩子接受抗生素时，大量父母报告了不良事件。几位父母在治疗方面遇到了额外的困难，一些在第4天结束治疗。
■NCT02496559；结果。
在OOH服务机构治疗的有发烧或呼吸道症状的儿童经历类似的症状或旷工持续时间，不管抗生素治疗。由于不良事件，父母经常选择过早终止抗生素治疗。味道不好,或者他们觉得治疗是不必要的.儿童在开抗生素时经常会出现不良事件，主要是胃肠道症状。
■要评估症状持续时间，治疗长度,以及儿童抗生素治疗的不良事件。
■在挪威急诊初级保健的四个非工作时间服务和一个儿科急诊诊所进行的观察性研究。
■266名0至6岁有发热或呼吸道症状的儿童。
■幼儿园/学校的症状和缺勤时间，治疗长度,并报告不良事件。
■症状持续时间没有差异，比较规定（30.8％）和未规定（69.2％）抗生素组的发热或旷工。在分析中耳炎亚组时，这种差异仍然存在。在该组中开了抗生素，84.5%的父母报告给予抗生素5-7天，50.7%报告没有困难。42.3％的病例报告了抗生素的不良事件，绝大多数是胃肠道紊乱。
■有发热或呼吸道症状的儿童无论使用何种抗生素治疗，症状持续时间和缺勤时间相似。当孩子接受抗生素时，大量父母报告了不良事件。几位父母在治疗方面遇到了额外的困难，一些在第4天结束治疗。
■NCT02496559；结果。
在OOH服务机构治疗的有发烧或呼吸道症状的儿童经历类似的症状或旷工持续时间，不管抗生素治疗。由于不良事件，父母经常选择过早终止抗生素治疗。味道不好,或者他们觉得治疗是不必要的.儿童在开抗生素时经常会出现不良事件，主要是胃肠道症状。
