PDF(Pubmed)
Abstract：
Pulmonary disease represents a substantial global health burden. Increased air pollution, especially fine particulate matter (PM2.5) is the most concerned proportion of air pollutants to respiratory health. PM2.5 may carry or combine with other toxic allergens and heavy metals, resulting in serious respiratory allergies and anaphylactic reactions in the host. Available treatment options such as antihistamines, steroids, and avoiding allergens/dust/pollutants could be limited due to certain side effects and immense exposure to air pollutants, especially in most polluted countries. In this mini-review, we summarized how PM2.5 triggers respiratory hyperresponsiveness and inflammation, and the probiotic Lactiplantibacillus plantarum supplementation could minimize the risk of the same. L. plantarum may confer beneficial effects in PM2.5-associated pulmonary inflammation due to significant antioxidant potential. We discussed L. plantarum\'s effect on PM2.5-induced reactive oxygen species (ROS), inflammatory cytokines, lipid peroxidation, and DNA damage. Available preclinical evidence shows L. plantarum induces gut-lung axis, SCFA, GABA, and other neurotransmitter signaling via gut microbiota modulation. SCFA signals are important in maintaining lung homeostasis and regulating intracellular defense mechanisms in alveolar cells. However, significant research is needed in this direction to contemplate L. plantarum\'s therapeutic potential in pulmonary allergies.
摘要：
肺部疾病是一个巨大的全球健康负担。空气污染增加，尤其是细颗粒物(PM2.5)是对呼吸道健康最为关注的空气污染物。PM2.5可能携带或与其他有毒过敏原和重金属结合，导致宿主严重的呼吸道过敏和过敏反应。可用的治疗选择，如抗组胺药，类固醇,由于某些副作用和大量暴露于空气污染物，避免过敏原/灰尘/污染物可能会受到限制，尤其是在污染最严重的国家。在这个小型审查中，我们总结了PM2.5如何引发呼吸高反应性和炎症，补充益生菌植物乳杆菌可以将其风险降至最低。由于显着的抗氧化潜力，植物乳杆菌可能在PM2.5相关的肺部炎症中产生有益作用。我们讨论了植物乳杆菌对PM2.5诱导的活性氧（ROS）的影响，炎性细胞因子，脂质过氧化，和DNA损伤。现有的临床前证据表明，植物乳杆菌诱导肠-肺轴，SCFA,GABA,和其他神经递质信号通过肠道微生物群的调节。SCFA信号在维持肺稳态和调节肺泡细胞的细胞内防御机制方面很重要。然而,在这个方向上需要进行重要的研究，以考虑植物乳杆菌在肺部过敏中的治疗潜力。
