PDF(Pubmed)
Abstract：
UNASSIGNED: The effect of vitamin A on the manifestations of liver fibrosis is controversial and establishing the causes of its multidirectional influence is an urgent problem. In the work, the functional characteristics of the liver with Cu-induced fibrosis were determined after the restoration of vitamin A to the control level at the F0/F1 stage.
UNASSIGNED: In animals with liver fibrosis, classical indicators of physiology, functional activity of the liver, histological, and hematological characteristics were determined; the content of calcium and ROS was determined in bone marrow cells.
UNASSIGNED: It was shown that in the liver with Cu-induced fibrosis, the restoration of vitamin A content to control values after per os injections of a retinol acetate solution at a dose of 0.10 mg (300 IU)/100 g of body weight in the early stages of this pathology development (Fо/F1) was accompanied by: a decrease in the number of immunocompetent cells in the bloodstream to control values; normalization of the amount of calcium ions and ROS in bone marrow cells; restoration to the control level of activity of alkaline phosphatase; an increase in the number of binuclear hepatocytes; and restoration of the dynamics of body weight growth in experimental animals, even against the background of the ongoing action of the hepatotoxic factor.
UNASSIGNED: We came to the conclusion that the multidirectional action of vitamin A, which occurs in liver fibrosis, depends not only on the concentration of vitamin A in the liver but also on temporal characteristics of cellular and metabolic links involved in the adaptive response formation. It was suggested that knowledge of the initial temporal metabolic characteristics and the amount of vitamin A in the liver, taking into account the stages of fibrosis development, can be an effective way to restore the altered homeostatic parameters of the body.
UNASSIGNED: In animals with liver fibrosis, classical indicators of physiology, functional activity of the liver, histological, and hematological characteristics were determined; the content of calcium and ROS was determined in bone marrow cells.
UNASSIGNED: It was shown that in the liver with Cu-induced fibrosis, the restoration of vitamin A content to control values after per os injections of a retinol acetate solution at a dose of 0.10 mg (300 IU)/100 g of body weight in the early stages of this pathology development (Fо/F1) was accompanied by: a decrease in the number of immunocompetent cells in the bloodstream to control values; normalization of the amount of calcium ions and ROS in bone marrow cells; restoration to the control level of activity of alkaline phosphatase; an increase in the number of binuclear hepatocytes; and restoration of the dynamics of body weight growth in experimental animals, even against the background of the ongoing action of the hepatotoxic factor.
UNASSIGNED: We came to the conclusion that the multidirectional action of vitamin A, which occurs in liver fibrosis, depends not only on the concentration of vitamin A in the liver but also on temporal characteristics of cellular and metabolic links involved in the adaptive response formation. It was suggested that knowledge of the initial temporal metabolic characteristics and the amount of vitamin A in the liver, taking into account the stages of fibrosis development, can be an effective way to restore the altered homeostatic parameters of the body.
摘要：
■维生素A对肝纤维化表现的影响是有争议的，建立其多方向影响的原因是一个紧迫的问题。在工作中,在F0/F1阶段将维生素A恢复至对照水平后，确定了具有Cu诱导的纤维化的肝脏的功能特征。
■在患有肝纤维化的动物中，经典的生理学指标，肝脏的功能活动，组织学,和血液学特征测定；测定骨髓细胞中钙和ROS的含量。
■结果表明，在Cu诱导的纤维化的肝脏中，在这种病理发展的早期阶段，以0.10mg（300IU）/100g体重的剂量注射视黄醇乙酸酯溶液后，维生素A含量恢复到对照值（Fdo/F1）伴随着：血流中免疫活性细胞数量减少至对照值；骨髓细胞中钙离子和ROS的量正常化；恢复到碱性磷酸酶活性的控制水平；恢复到实验动物体内肝细胞的数量和肝细胞的增长；即使在肝毒性因子持续作用的背景下。
■我们得出的结论是维生素A的多方向作用，发生在肝纤维化中，不仅取决于肝脏中维生素A的浓度，还取决于适应性反应形成中涉及的细胞和代谢联系的时间特征。有人建议了解肝脏的初始时间代谢特征和维生素A的含量，考虑到纤维化发展的阶段，可以是恢复身体改变的稳态参数的有效方法。
■在患有肝纤维化的动物中，经典的生理学指标，肝脏的功能活动，组织学,和血液学特征测定；测定骨髓细胞中钙和ROS的含量。
■结果表明，在Cu诱导的纤维化的肝脏中，在这种病理发展的早期阶段，以0.10mg（300IU）/100g体重的剂量注射视黄醇乙酸酯溶液后，维生素A含量恢复到对照值（Fdo/F1）伴随着：血流中免疫活性细胞数量减少至对照值；骨髓细胞中钙离子和ROS的量正常化；恢复到碱性磷酸酶活性的控制水平；恢复到实验动物体内肝细胞的数量和肝细胞的增长；即使在肝毒性因子持续作用的背景下。
■我们得出的结论是维生素A的多方向作用，发生在肝纤维化中，不仅取决于肝脏中维生素A的浓度，还取决于适应性反应形成中涉及的细胞和代谢联系的时间特征。有人建议了解肝脏的初始时间代谢特征和维生素A的含量，考虑到纤维化发展的阶段，可以是恢复身体改变的稳态参数的有效方法。
