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Abstract：
Avian trichomoniasis, caused by the protozoan parasite Trichomonas gallinae, is a prevalent and economically significant disease in pigeons. This study investigated the drug resistance of T. gallinae isolates in Guangdong Province, China. The results revealed that 25.3% (20/79) of the isolates were resistant to one or more of the four nitroimidazole drugs tested, namely, metronidazole, dimetridazole, secnidazole, and tinidazole. Secnidazole elicited the highest resistance rate (19.0%; 15/79), followed by tinidazole (17.7%; 14/79), metronidazole (17.7%; 14/79), and dimetridazole (13.9%; 11/79). An enormous majority of the resistant isolates (70.0%; 14/20) exhibited resistance to multiple drugs. Additionally, the resistance rate was significantly higher in isolates from birds aged < 30 days (53.3%; 8/15) than in those from older birds (23.1%; 12/52). Moreover, no drug resistance was detected in female pigeons. The genotype of the isolated strain was also associated with drug resistance. Specifically, 50.0% (15/30) of ITS-B genotypes exhibited resistance to drugs, while only 10.2% (5/49) of ITS-A genotypes demonstrated resistance. This study also found the growth characteristics of different Trichomonas isolates to be influenced by their genotypes and initial inoculum concentrations. These findings underscore the urgent need for effective measures to control and prevent drug-resistant T. gallinae infections in pigeons, thus ensuring the stable development of the pigeon industry.
摘要：
禽滴虫病,由原生动物寄生虫毛滴虫引起的，是鸽子中一种普遍且具有经济意义的疾病。本研究调查了广东省鸡巴分离株的耐药性。中国。结果显示25.3%(20/79)的分离株对所测试的四种硝基咪唑类药物中的一种或多种耐药,即,甲硝唑,dimetridazole,塞克硝唑,还有替硝唑.塞克硝唑引起的耐药率最高(19.0%;15/79),其次是替硝唑（17.7％；14/79），甲硝唑（17.7%；14/79），和二甲咪唑（13.9%；11/79）。绝大多数耐药分离株（70.0％；14/20）对多种药物表现出耐药性。此外,<30天的鸟类分离株的耐药率显着高于年龄较大的鸟类分离株（53.3％；8/15）（23.1％；12/52）。此外，在雌鸽中没有检测到耐药性。分离菌株的基因型也与耐药性有关。具体来说,50.0%(15/30)的ITS-B基因型表现出耐药性，而只有10.2％（5/49）的ITS-A基因型表现出抗性。这项研究还发现，不同的毛滴虫分离株的生长特性受其基因型和初始接种物浓度的影响。这些发现强调迫切需要采取有效措施来控制和预防鸽子中耐药的胆虫感染，从而确保鸽子产业的稳定发展。
