PDF(Pubmed)
Abstract：
UNASSIGNED: Sleep loss contributes to various health issues and impairs neurological function. Molecular hydrogen has recently gained popularity as a nontoxic ergogenic and health promoter. The effect of molecular hydrogen on sleep and sleep-related neural systems remains unexplored. This study investigates the impact of hydrogen-rich water (HRW) on sleep behavior and neuronal activation in sleep-deprived mice.
UNASSIGNED: Adult C57BL/6J mice were implanted with electroencephalography (EEG) and electromyography (EMG) recording electrodes and given HRW (0.7-1.4 mM) or regular water for 7 days ad libitum. Sleep-wake cycles were recorded under baseline conditions and after acute sleep loss. Neuronal activation in sleep- and wake-related regions was assessed using cFos immunostaining.
UNASSIGNED: HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. HRW also decreased the average amount of time for mice to fall asleep after light onset. Neuronal activation in the lateral septum, medial septum, ventrolateral preoptic area, and median preoptic area was significantly altered in all mice treated with HRW.
UNASSIGNED: HRW improves sleep consolidation and increases neuronal activation in sleep-related brain regions. It may serve as a simple, effective treatment to improve recovery after sleep loss.
UNASSIGNED: Adult C57BL/6J mice were implanted with electroencephalography (EEG) and electromyography (EMG) recording electrodes and given HRW (0.7-1.4 mM) or regular water for 7 days ad libitum. Sleep-wake cycles were recorded under baseline conditions and after acute sleep loss. Neuronal activation in sleep- and wake-related regions was assessed using cFos immunostaining.
UNASSIGNED: HRW increased sleep consolidation in undisturbed mice and increased non-rapid-eye movement and rapid-eye-movement sleep amount in sleep-deprived mice. HRW also decreased the average amount of time for mice to fall asleep after light onset. Neuronal activation in the lateral septum, medial septum, ventrolateral preoptic area, and median preoptic area was significantly altered in all mice treated with HRW.
UNASSIGNED: HRW improves sleep consolidation and increases neuronal activation in sleep-related brain regions. It may serve as a simple, effective treatment to improve recovery after sleep loss.
摘要：
■睡眠不足会导致各种健康问题并损害神经功能。分子氢最近作为无毒的人体和健康促进剂而受到欢迎。分子氢对睡眠和睡眠相关神经系统的影响仍未被探索。这项研究调查了富氢水（HRW）对睡眠剥夺小鼠的睡眠行为和神经元激活的影响。
■将成年C57BL/6J小鼠植入脑电图（EEG）和肌电图（EMG）记录电极，并随意给予HRW（0.7-1.4mM）或常规水7天。在基线条件下和急性睡眠不足后记录睡眠-觉醒周期。使用cFos免疫染色评估睡眠和唤醒相关区域中的神经元激活。
■HRW增加了未受干扰小鼠的睡眠巩固，并增加了睡眠剥夺小鼠的非快速眼动和快速眼动睡眠量。HRW还减少了小鼠在轻度发作后入睡的平均时间。外侧隔的神经元激活，内侧隔,腹外侧视前区,在所有接受HRW治疗的小鼠中，中位视前区都发生了显着变化。
■HRW改善睡眠巩固并增加睡眠相关脑区的神经元激活。它可以作为一个简单的，有效的治疗，以改善睡眠损失后的恢复。
■将成年C57BL/6J小鼠植入脑电图（EEG）和肌电图（EMG）记录电极，并随意给予HRW（0.7-1.4mM）或常规水7天。在基线条件下和急性睡眠不足后记录睡眠-觉醒周期。使用cFos免疫染色评估睡眠和唤醒相关区域中的神经元激活。
■HRW增加了未受干扰小鼠的睡眠巩固，并增加了睡眠剥夺小鼠的非快速眼动和快速眼动睡眠量。HRW还减少了小鼠在轻度发作后入睡的平均时间。外侧隔的神经元激活，内侧隔,腹外侧视前区,在所有接受HRW治疗的小鼠中，中位视前区都发生了显着变化。
■HRW改善睡眠巩固并增加睡眠相关脑区的神经元激活。它可以作为一个简单的，有效的治疗，以改善睡眠损失后的恢复。
