Abstract：
BACKGROUND: Adamantinomas are rare malignant bone tumors. Due to their low incidence, there are few reports on the clinical results of adamantinoma.
OBJECTIVE: This study aims to clarify outcomes in patients with adamantinoma using data from the National Bone and Soft Tissue Tumor Registry.
METHODS: From 2006 to 2019, 38 cases of tibial origin were included. Twenty-four were male and 14 were female, with a mean age of 37 (6-87) years and a mean follow-up of 35 (1-128) months.
RESULTS: Surgery was performed in 33 cases (87%) (curettage: 4 cases, wide resection: 27 cases, amputation: 2 cases). Reconstruction was performed in 27 patients who underwent wide resection. A total of 12 additional surgeries were performed in 11 patients. The main reason for the additional surgeries was nonunion of grafting bone in 6 cases. Oncologic outcomes were DOC (death from other causes) in one case and NED (no evidence of disease) in 37 cases.
CONCLUSIONS: The results of treatment of adamantinomas in Japan have been extremely favorable. This may be due in part to the large number of cases with wide resection.
OBJECTIVE: This study aims to clarify outcomes in patients with adamantinoma using data from the National Bone and Soft Tissue Tumor Registry.
METHODS: From 2006 to 2019, 38 cases of tibial origin were included. Twenty-four were male and 14 were female, with a mean age of 37 (6-87) years and a mean follow-up of 35 (1-128) months.
RESULTS: Surgery was performed in 33 cases (87%) (curettage: 4 cases, wide resection: 27 cases, amputation: 2 cases). Reconstruction was performed in 27 patients who underwent wide resection. A total of 12 additional surgeries were performed in 11 patients. The main reason for the additional surgeries was nonunion of grafting bone in 6 cases. Oncologic outcomes were DOC (death from other causes) in one case and NED (no evidence of disease) in 37 cases.
CONCLUSIONS: The results of treatment of adamantinomas in Japan have been extremely favorable. This may be due in part to the large number of cases with wide resection.
摘要：
背景：金刚烷胺瘤是一种罕见的恶性骨肿瘤。由于发病率低,关于金刚烷瘤的临床结果的报道很少。
目的：本研究旨在使用来自国家骨和软组织肿瘤注册中心的数据阐明金刚烷胺瘤患者的预后。
方法：从2006年至2019年，纳入38例胫骨起源患者。二十四个是男性，十四个是女性，平均年龄37（6-87）岁，平均随访35（1-128）个月。
结果：手术33例（87％）（刮宫：4例，广泛切除：27例，截肢：2例）。对27例接受广泛切除的患者进行了重建。11例患者共进行了12次手术。增加手术的主要原因是6例移植骨不连。肿瘤学结果为DOC（其他原因死亡）1例，NED（无疾病证据）37例。
结论：在日本，金刚烷胺瘤的治疗效果非常好。这可能部分是由于大量病例广泛切除。
目的：本研究旨在使用来自国家骨和软组织肿瘤注册中心的数据阐明金刚烷胺瘤患者的预后。
方法：从2006年至2019年，纳入38例胫骨起源患者。二十四个是男性，十四个是女性，平均年龄37（6-87）岁，平均随访35（1-128）个月。
结果：手术33例（87％）（刮宫：4例，广泛切除：27例，截肢：2例）。对27例接受广泛切除的患者进行了重建。11例患者共进行了12次手术。增加手术的主要原因是6例移植骨不连。肿瘤学结果为DOC（其他原因死亡）1例，NED（无疾病证据）37例。
结论：在日本，金刚烷胺瘤的治疗效果非常好。这可能部分是由于大量病例广泛切除。
