PDF(Pubmed)
Abstract：
Malakoplakia is a rare granulomatous disease. Its aetiology is unclear but possible theories include infection with microorganisms (especially Escherichia coli), immunosuppression and impaired lysosomal function. It has been commonly documented to affect the genitourinary tract but can affect any organ, with the gastrointestinal system being the next most affected. We present a woman in her 70s, with a 2-week history of right-sided abdominal pain, 13 years following her renal transplant. She was admitted for treatment of an E. coli bacteraemia. CT scan had shown a caecal pole mass, highly suspicious for malignancy. It was surgically resected, and histology revealed findings of malakoplakia within the colon. Surgical intervention was combined with a prolonged course of antibiotics for successful treatment. We highlight the ability of malakoplakia to mimic malignancy and should be considered in the differentials in the context of an immunosuppressed patient with radiological findings of a colonic mass.
摘要：
马拉斑病是一种罕见的肉芽肿性疾病。其病因尚不清楚，但可能的理论包括感染微生物（尤其是大肠杆菌），免疫抑制和溶酶体功能受损。它通常被证明会影响泌尿生殖道，但可以影响任何器官，胃肠系统是下一个受影响最严重的。我们介绍了一个70多岁的女人，有2周的右侧腹痛病史，在她接受肾移植13年后.她因治疗大肠杆菌菌血症而入院。CT扫描显示有盲肠极肿块,高度怀疑恶性肿瘤。手术切除了,和组织学显示结肠内的malakoplakia的发现。手术干预与延长疗程的抗生素相结合，以成功治疗。我们强调了Malakoplakia模仿恶性肿瘤的能力，在具有结肠肿块放射学发现的免疫抑制患者的情况下，应在差异中予以考虑。
