Mesh : Humans Constipation / diagnosis etiology therapy Gastrointestinal Diseases / diagnosis etiology therapy Levodopa / pharmacology Parkinson Disease / complications diagnosis drug therapy

来  源:   DOI:10.1097/MCG.0000000000001961   PDF(Pubmed)

Abstract:
Gastrointestinal symptoms in Parkinson\'s disease (PD) are among the most prevalent and debilitating of complications and present unique diagnostic and management challenges. Patients with PD commonly experience dysphagia, nausea, bloating, and constipation related to pathologic involvement of the enteric nervous system. In turn, gastrointestinal complications may impact motor fluctuations and the efficacy of levodopa therapy. This review will explore the common gastrointestinal manifestations of PD with an emphasis on clinical presentation, workup, and treatment strategies.
摘要:
帕金森病(PD)的胃肠道症状是最普遍和最衰弱的并发症之一,并提出了独特的诊断和管理挑战。PD患者通常会出现吞咽困难,恶心,腹胀,和便秘与肠神经系统的病理性受累有关。反过来,胃肠道并发症可能会影响运动波动和左旋多巴治疗的疗效。本综述将探讨PD的常见胃肠道表现,重点是临床表现。workup,和治疗策略。
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