PDF(Pubmed)
Abstract：
Autoimmune encephalitis (AE) is the result of an autoimmune process that occurs as a rapidly advancing encephalopathy. Autoimmune encephalitis was commonly linked to herpes simplex virus 1 (HSV-1) as the most frequently identified virus. The main areas affected by this invasion are the temporal lobe, frontal lobe, and limbic system. Limbic encephalitis is a highly uncommon occurrence involving anti-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) encephalitis and anti-IgLON family member 5 (IgLON5) disease, both belonging to the rare category. As far as we know, this is the first report showing that a patient diagnosed with AMPAR encephalitis overlapped with anti-IgLON5 disease post herpes simplex virus encephalitis (HSE), which helps to broaden the range of this uncommon autoimmune disease. We recommend autoantibody testing in all patients with HSE, particularly those involving neurological relapses or progression.
摘要：
自身免疫性脑炎（AE）是自身免疫过程的结果，作为快速发展的脑病发生。自身免疫性脑炎通常与单纯疱疹病毒1（HSV-1）相关，是最常见的病毒。受这次入侵影响的主要区域是颞叶，额叶,和边缘系统。边缘叶脑炎是一种非常罕见的事件，涉及抗α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPAR）脑炎和抗IgLON家族成员5（IgLON5）疾病，都属于稀有类。据我们所知,这是第一份报告显示一名诊断为AMPAR脑炎的患者与单纯疱疹病毒性脑炎（HSE）后的抗IgLON5疾病重叠，这有助于扩大这种罕见的自身免疫性疾病的范围。我们建议对所有HSE患者进行自身抗体检测，特别是那些涉及神经系统复发或进展的患者。
