Role of Fecal Microbiota Transplantation in Managing Clostridium Difficile Infection and Inflammatory Bowel Disease: A Narrative Review.

粪便微生物移植在管理艰难梭菌感染和炎症性肠病中的作用 ： 叙事综述。

• 发表时间: 2023 Dec
• 来源期刊: Cureus
• DOI: 10.7759/cureus.51004
• PMID: 38259389
• 文章类型: Journal Article
• 作者列表: Ghazanfar H,Kandhi S,Acherjee T,Qureshi ZA,Shaban M,Yordanka DS,Cordero D,Chinta S,Jyala A,Patel H

关键词: clostridium difficile; fecal microbiota transplantation; gut dysbiosis; inflammatory bowel disease; severe cdi

Abstract

Fecal microbiota transplantation (FMT) has been emerging as an alternate treatment modality in the management of patients with dysbiosis by restoring abnormal gut microbiota composition through the transplantation of normal fecal microbiota from healthy donors. This technique has lately gained a lot of attention in the treatment of recurrent or refractory Clostridium difficile infection (CDI) owing to its high success rates combined with its favorable safety profile. FMT has also been attracting the interest of clinicians as a new treatment option for inflammatory bowel diseases (IBD). Here, we reviewed most of the recent advancements in the use of FMT for CDI as well as its use in the treatment of IBD.

摘要

粪便微生物群移植（FMT）已成为通过从健康供体移植正常粪便微生物群恢复异常肠道微生物群组成来管理生态失调患者的替代治疗方式。由于该技术的高成功率和良好的安全性，该技术最近在复发性或难治性艰难梭菌感染（CDI）的治疗中获得了很多关注。FMT作为炎症性肠病（IBD）的新治疗选择也引起了临床医生的兴趣。这里,我们回顾了FMT用于CDI的最新进展及其在IBD治疗中的应用.