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Abstract：
Infection with the coccidian parasite Toxoplasma gondii was associated with an increased risk of several mental disorders. We conducted a case-control study of 464 consecutive psychiatric patients and assessed the prevalence of IgG antibodies against T. gondii and the potential risk factors associated with infection. T. gondii-specific antibodies were determined using a chemiluminescence assay. A questionnaire was utilized to assess the potential correlation between risk factors and Toxoplasma gondii seropositivity. IgG antibodies were found in 325 (70.04%) of the patients. We observed a higher likelihood of positive IgG antibodies against Toxoplasma gondii in older individuals, patients residing in rural areas, and females. We also noted associations between Toxoplasma gondii infection and certain risk factors, like activities that involve contact with soil, low-income levels, and limited educational attainment. Our findings indicate a high prevalence of T. gondii infection among psychiatric patients from Western Romania and provide new information regarding the potential risk factors associated with T. gondii in this population group. This study may serve as a foundation for future research and the development of preventive strategies.
摘要：
感染球虫寄生虫弓形虫与几种精神障碍的风险增加有关。我们对464名连续精神病患者进行了病例对照研究，并评估了弓形虫IgG抗体的患病率以及与感染相关的潜在危险因素。使用化学发光测定法测定弓形虫特异性抗体。使用问卷评估危险因素与弓形虫血清阳性之间的潜在相关性。在325例患者中发现了IgG抗体（70.04％）。我们观察到老年个体中弓形虫IgG抗体阳性的可能性更高，居住在农村地区的病人，和女性。我们还注意到弓形虫感染与某些危险因素之间的关联，比如与土壤接触的活动，低收入水平,和有限的教育程度。我们的发现表明，罗马尼亚西部的精神病患者中弓形虫感染率很高，并提供了有关该人群中与弓形虫相关的潜在危险因素的新信息。这项研究可以作为未来研究和预防策略制定的基础。
