PDF(Pubmed)
Abstract：
Obesity represents an important public health concern, being one of the leading causes of death worldwide. It is a multifactorial disease with many underlying intertwined causes, including genetic, environmental and behavioral factors. Notably, metabolism-disrupting chemicals (MDCs) can alter the set point control of metabolism, affecting the development and function of the adipose tissue. Epidemiological studies have reported associations between human exposure to MDCs and several altered metabolic endpoints. It is also noteworthy that sex and gender represent important risk factors in the development of obesity. Different sex-related biological and physiological characteristics influence individual susceptibility, whereas gender represents a critical component in determining the different exposure scenarios. Although some advancements in the treatment of obesity have been achieved in preclinical and clinical studies, the obesity pandemic continues to increase worldwide. The present study performed a systematic review of recent studies considering the effects of MDCs on obesity, with a specific focus on sex- and gender-related responses. This review highlighted that MDCs could differently affect men and women at different stages of life even though the number of studies evaluating the association between obesity and MDC exposure in relation to sex and gender is still limited. This evidence should urge researchers to carry out studies considering sex and gender differences. This is essential for developing sex-/gender-tailored prevention strategies to improve public health policies and reduce exposure.
摘要：
肥胖是一个重要的公共卫生问题，是全球死亡的主要原因之一。这是一种多因素疾病，有许多潜在的相互交织的原因，包括遗传,环境和行为因素。值得注意的是,代谢干扰化学物质（MDC）可以改变代谢的设定点控制，影响脂肪组织的发育和功能。流行病学研究报告了人类暴露于MDCs与几个改变的代谢终点之间的关联。同样值得注意的是，性别和性别是肥胖发展的重要危险因素。不同性别相关的生物学和生理特征影响个体易感性,而性别是确定不同暴露场景的关键组成部分。尽管在临床前和临床研究中已经取得了一些进展，肥胖流行在全球范围内继续增加。本研究对最近的研究进行了系统评价，这些研究考虑了MDCs对肥胖的影响，特别关注与性别和性别相关的反应。这篇综述强调，尽管评估肥胖和MDC暴露与性别和性别之间关系的研究数量仍然有限，但MDC在不同生命阶段可能会对男性和女性产生不同的影响。这些证据应敦促研究人员进行考虑性别和性别差异的研究。这对于制定针对性别/性别的预防战略以改善公共卫生政策和减少接触至关重要。
