PDF(Pubmed)
Abstract：
This study investigated the intricate dynamics of intranasal spray deposition within nasal models, considering variations in head orientation and stages of the nasal cycle. Employing controlled delivery conditions, we compared the deposition patterns of saline nasal sprays in models representing congestion (N1), normal (N0), and decongestion (P1, P2) during one nasal cycle. The results highlighted the impact of the nasal cycle on spray distribution, with congestion leading to confined deposition and decongestion allowing for broader dispersion of spray droplets and increased sedimentation towards the posterior turbinate. In particular, the progressive nasal dilation from N1 to P2 decreased the spray deposition in the middle turbinate. The head angle, in conjunction with the nasal cycle, significantly influenced the nasal spray deposition distribution, affecting targeted drug delivery within the nasal cavity. Despite controlled parameters, a notable variance in deposition was observed, emphasizing the complex interplay of gravity, flow shear, nasal cycle, and nasal morphology. The magnitude of variance increased as the head tilt angle increased backward from upright to 22.5° to 45° due to increasing gravity and liquid film destabilization, especially under decongestion conditions (P1, P2). This study\'s findings underscore the importance of considering both natural physiological variations and head orientation in optimizing intranasal drug delivery.
摘要：
这项研究调查了鼻内喷雾沉积在鼻模型中的复杂动力学，考虑头部方向和鼻周期阶段的变化。采用受控交付条件，我们比较了代表充血（N1）的模型中盐水鼻腔喷雾剂的沉积模式，正常（N0），和一个鼻周期内的充血（P1，P2）。结果强调了鼻循环对喷雾分布的影响，充血导致有限的沉积和去充血，从而使喷雾液滴更广泛地分散并增加了向后鼻甲的沉积。特别是,从N1到P2的进行性鼻扩张减少了中鼻甲的喷雾沉积。头部角度，与鼻周期相结合，显著影响鼻腔喷雾沉积分布，影响鼻腔内的靶向药物递送。尽管参数受控,观察到沉积的显着差异，强调重力的复杂相互作用，流动剪切,鼻周期,和鼻形态。由于重力和液膜失稳的增加，随着头倾角从直立向后增加到22.5°到45°，变化的幅度增加。特别是在解充症条件下（P1，P2）。这项研究的发现强调了在优化鼻内药物递送中考虑自然生理变化和头部取向的重要性。
