PDF(Pubmed)
Abstract：
BACKGROUND: Infertility affects about 80 million individuals worldwide and 10-15% of couples at reproductive age will seek medical assistance. There is increasing evidence that pregnancies after Assisted Reproduction Techniques (ART) are associated with pre-term birth, low birthweight, congenital defects, and increased mortality rates. The aim of this review is to assess all the published literature and provide an updated review on the effect of assisted conception and perinatal and neonatal outcomes.
METHODS: Comprehensive research on Pubmed/Medline, Scopus, and Google scholar electronic databases was conducted from July 2023 up to September 2023, using the terms assisted reproductive techniques, ART, in vitro fertilization, IVF, intracytoplasmic sperm injection, ICSI, preterm birth, PTB, low birth weight, LBW, chromosomal defects, congenital defects, and hypospadias. In total, 87 full text articles were retrieved and after a careful evaluation, 31 studies were selected for data extraction.
RESULTS: Our review demonstrated a higher risk of congenital and chromosomal defects, and a higher incidence of male genital tract defects and heart defects in ART pregnancies. Regarding pre-term birth, our results were contradictory.
CONCLUSIONS: Although assisted reproduction techniques are associated with increased risks, they are safe regarding perinatal outcomes and couples should not be discouraged from utilizing them. Our results aim to alert clinicians to these specific outcomes and offer more personalized care and counseling to infertile couples and their children.
METHODS: Comprehensive research on Pubmed/Medline, Scopus, and Google scholar electronic databases was conducted from July 2023 up to September 2023, using the terms assisted reproductive techniques, ART, in vitro fertilization, IVF, intracytoplasmic sperm injection, ICSI, preterm birth, PTB, low birth weight, LBW, chromosomal defects, congenital defects, and hypospadias. In total, 87 full text articles were retrieved and after a careful evaluation, 31 studies were selected for data extraction.
RESULTS: Our review demonstrated a higher risk of congenital and chromosomal defects, and a higher incidence of male genital tract defects and heart defects in ART pregnancies. Regarding pre-term birth, our results were contradictory.
CONCLUSIONS: Although assisted reproduction techniques are associated with increased risks, they are safe regarding perinatal outcomes and couples should not be discouraged from utilizing them. Our results aim to alert clinicians to these specific outcomes and offer more personalized care and counseling to infertile couples and their children.
摘要：
背景：全世界约有8000万人患有不孕症，10-15％的育龄夫妇将寻求医疗援助。越来越多的证据表明，辅助生殖技术（ART）后的怀孕与早产有关。低出生体重,先天性缺陷,死亡率上升。本综述的目的是评估所有已发表的文献，并提供有关辅助受孕效果以及围产期和新生儿结局的最新综述。
方法：Pubmed/Medline的综合研究，Scopus,和谷歌学者电子数据库从2023年7月到2023年9月，使用辅助生殖技术，ART,体外受精,IVF,卵胞浆内单精子注射,ICSI,早产,PTB,低出生体重,LBW,染色体缺陷,先天性缺陷,和尿道下裂.总的来说,检索到87篇全文，经过仔细评估，选择31项研究进行数据提取。
结果：我们的审查表明，先天性和染色体缺陷的风险更高，ART妊娠中男性生殖道缺陷和心脏缺陷的发生率较高。关于早产，我们的结果是矛盾的。
结论：尽管辅助生殖技术与风险增加有关，它们在围产期结局方面是安全的，不应阻止夫妇使用它们。我们的研究结果旨在提醒临床医生注意这些具体结果，并为不育夫妇及其子女提供更个性化的护理和咨询。
方法：Pubmed/Medline的综合研究，Scopus,和谷歌学者电子数据库从2023年7月到2023年9月，使用辅助生殖技术，ART,体外受精,IVF,卵胞浆内单精子注射,ICSI,早产,PTB,低出生体重,LBW,染色体缺陷,先天性缺陷,和尿道下裂.总的来说,检索到87篇全文，经过仔细评估，选择31项研究进行数据提取。
结果：我们的审查表明，先天性和染色体缺陷的风险更高，ART妊娠中男性生殖道缺陷和心脏缺陷的发生率较高。关于早产，我们的结果是矛盾的。
结论：尽管辅助生殖技术与风险增加有关，它们在围产期结局方面是安全的，不应阻止夫妇使用它们。我们的研究结果旨在提醒临床医生注意这些具体结果，并为不育夫妇及其子女提供更个性化的护理和咨询。
