PDF(Pubmed)
Abstract：
While the vertebrate immune system consists of innate and adaptive branches, invertebrates only have innate immunity. This feature makes them an ideal model system for studying the cellular and molecular mechanisms of innate immunity sensu stricto without reciprocal interferences from adaptive immunity. Although invertebrate immunity is evolutionarily older and a precursor of vertebrate immunity, it is far from simple. Despite lacking lymphocytes and functional immunoglobulin, the invertebrate immune system has many sophisticated mechanisms and features, such as long-term immune memory, which, for decades, have been exclusively attributed to adaptive immunity. In this review, we describe the cellular and molecular aspects of invertebrate immunity, including the epigenetic foundation of innate memory, the transgenerational inheritance of immunity, genetic immunity against invading transposons, the mechanisms of self-recognition, natural transplantation, and germ/somatic cell parasitism.
摘要：
虽然脊椎动物免疫系统由先天和适应性分支组成，无脊椎动物只有先天免疫力。此功能使它们成为研究严格的先天免疫的细胞和分子机制的理想模型系统，而不会受到适应性免疫的相互干扰。尽管无脊椎动物免疫在进化上更古老，是脊椎动物免疫的前身，它远非简单。尽管缺乏淋巴细胞和功能性免疫球蛋白，无脊椎动物免疫系统具有许多复杂的机制和特征，比如长期免疫记忆，which,几十年来,完全归因于适应性免疫。在这次审查中,我们描述了无脊椎动物免疫的细胞和分子方面，包括先天记忆的表观遗传基础，免疫的跨代遗传,针对入侵转座子的遗传免疫，自我识别的机制，自然移植,和胚芽/体细胞寄生。
