PDF(Pubmed)
Abstract：
Pancreatic cancer, notorious for its grim 10% five-year survival rate, poses significant clinical challenges, largely due to late-stage diagnosis and limited therapeutic options. This review delves into the generation of organoids, including those derived from resected tissues, biopsies, pluripotent stem cells, and adult stem cells, as well as the advancements in 3D printing. It explores the complexities of the tumor microenvironment, emphasizing culture media, the integration of non-neoplastic cells, and angiogenesis. Additionally, the review examines the multifaceted properties of graphene oxide (GO), such as its mechanical, thermal, electrical, chemical, and optical attributes, and their implications in cancer diagnostics and therapeutics. GO\'s unique properties facilitate its interaction with tumors, allowing targeted drug delivery and enhanced imaging for early detection and treatment. The integration of GO with 3D cultured organoid systems, particularly in pancreatic cancer research, is critically analyzed, highlighting current limitations and future potential. This innovative approach has the promise to transform personalized medicine, improve drug screening efficiency, and aid biomarker discovery in this aggressive disease. Through this review, we offer a balanced perspective on the advancements and future prospects in pancreatic cancer research, harnessing the potential of organoids and GO.
摘要：
胰腺癌,以其严峻的10%的五年生存率而臭名昭著，带来了重大的临床挑战，主要是由于晚期诊断和有限的治疗选择。这篇综述深入研究了类器官的产生，包括那些来自切除组织的，活检,多能干细胞，和成体干细胞，以及3D打印的进步。它探讨了肿瘤微环境的复杂性，强调文化媒介，非肿瘤细胞的整合，和血管生成。此外,这篇综述考察了氧化石墨烯(GO)的多方面特性，比如它的机械，热,电气,化学,和光学属性，以及它们在癌症诊断和治疗中的意义。GO的独特性质促进其与肿瘤的相互作用，允许靶向药物递送和增强成像，以便早期发现和治疗。GO与3D培养的类器官系统的整合，特别是在胰腺癌研究中，进行了严格的分析，强调当前的局限性和未来的潜力。这种创新的方法有望改变个性化医疗，提高药物筛选效率，并帮助在这种侵袭性疾病中发现生物标志物。通过这次审查,我们对胰腺癌研究的进展和未来前景提供了一个平衡的观点，利用类器官和GO的潜力。
