PDF(Pubmed)
Abstract：
The aim of this study was to explore adherence to the Consolidated Standards of Reporting Trials (CONSORT) reporting standards in abstracts of randomized controlled trials on glaucoma. A cross-sectional observational study was conducted on the aforementioned abstracts, indexed in MEDLINE/PubMed between the years 2017 and 2021. In total, 302 abstracts met the inclusion criteria and were further analyzed. The median score of CONSORT-A items was 8 (interquartile range, 7-10) out of 17 (47.0%). Most analyzed studies were conducted in a single center (80.5%) and the abstracts were predominantly structured (95.0%). Only 20.5% of the abstracts adequately described the trial design, while randomization and funding were described by 6.0% of the abstracts. Higher overall scores were associated with structured abstracts, a multicenter setting, statistically significant results, funding by industry, a higher number of participants, and having been published in journals with impact factors above four (p < 0.001, respectively). The results of this study indicate a suboptimal adherence to CONSORT-A reporting standards, especially in particular items such as randomization and funding. Since these factors could contribute to the overall quality of the trials and further translation of trial results into clinical practice, an improvement in glaucoma research reporting transparency is needed.
摘要：
这项研究的目的是探索青光眼随机对照试验摘要中对合并报告试验标准（CONSORT）报告标准的遵守情况。对上述摘要进行了横断面观察研究，2017年至2021年期间在MEDLINE/PubMed中索引。总的来说,302篇摘要符合纳入标准，并进行了进一步分析。CONSORT-A项目的中位数得分为8分(四分位距，7-10）中的17个（47.0%）。大多数分析研究是在单个中心进行的（80.5%），摘要主要是结构化的（95.0%）。只有20.5%的摘要充分描述了试验设计，而6.0%的摘要描述了随机化和资助。较高的总分与结构化摘要相关，多中心设置，具有统计学意义的结果，行业资助，更多的参与者，并在影响因子高于4的期刊上发表(分别为p<0.001)。这项研究的结果表明，对CONSORT-A报告标准的依从性欠佳，特别是在诸如随机化和资助之类的特定项目中。由于这些因素可能有助于提高试验的整体质量，并将试验结果进一步转化为临床实践，需要提高青光眼研究报告的透明度.
