PDF(Pubmed)
Abstract：
Bovine leukemia virus (BLV) is a retrovirus that causes enzootic bovine leucosis (EBL), which is the most significant neoplastic disease in cattle. Although EBL has been successfully eradicated in most European countries, infections continue to rise in Argentina, Brazil, Canada, Japan, and the United States. BLV imposes a substantial economic burden on the cattle industry, particularly in dairy farming, as it leads to a decline in animal production performance and increases the risk of disease. Moreover, trade restrictions on diseased animals and products between countries and regions further exacerbate the problem. Recent studies have also identified fragments of BLV nucleic acid in human breast cancer tissues, raising concerns for public health. Due to the absence of an effective vaccine, controlling the disease is challenging. Therefore, it is crucial to accurately detect and diagnose BLV at an early stage to control its spread and minimize economic losses. This review provides a comprehensive examination of BLV, encompassing its genomic structure, epidemiology, modes of transmission, clinical symptoms, detection methods, hazards, and control strategies. The aim is to provide strategic information for future BLV research.
摘要：
牛白血病病毒（BLV）是一种逆转录病毒，可引起牛地方性白血病（EBL），这是牛最重要的肿瘤疾病。尽管EBL已在大多数欧洲国家成功根除，阿根廷的感染继续上升，巴西,加拿大,Japan,和美国。BLV给养牛业带来了巨大的经济负担，特别是在奶牛养殖中，因为它会导致动物生产性能下降并增加患病风险。此外，国家和地区之间对患病动物和产品的贸易限制进一步加剧了这一问题。最近的研究还确定了人乳腺癌组织中的BLV核酸片段，对公众健康的关注。由于缺乏有效的疫苗，控制疾病是具有挑战性的。因此,对BLV进行早期准确的检测和诊断,对控制其传播和减少经济损失至关重要。这篇综述提供了对BLV的全面审查，包括它的基因组结构，流行病学,传输模式，临床症状,检测方法,危害,和控制策略。目的是为未来的BLV研究提供战略信息。
