PDF(Pubmed)
Abstract：
Porcine epidemic diarrhea virus (PEDV) is a porcine enteric coronavirus, which is one of the main causative agents of porcine epidemic diarrhea (PED), with 100% morbidity and 80-100% mortality in neonatal piglets. Since 2010, large-scale PED caused by highly pathogenic variants of PEDV has occurred successively in China and other countries in the world, posing a great threat to the global pig industry. It has been demonstrated in many investigations that the classic attenuated vaccine strain, PEDV CV777, is insufficient to fully protect against the PEDV variants. Moreover, the maternally derived antibodies elicited by inactivated vaccines also cannot completely protect piglets from infection. In addition, feedback feeding poses a risk of periodic PEDV recurrence in pig farms, making it challenging to successfully limit the spread of PEDV in China. This review focuses on the etiology, epidemiology, antigenicity, and control strategies of PEDV in China and provides information for the formulation of effective control measures.
摘要：
猪流行性腹泻病毒(PEDV)是一种猪肠道冠状病毒,是猪流行性腹泻(PED)的主要致病因子之一,新生仔猪的发病率为100％，死亡率为80-100％。2010年以来,我国及世界各国相继发生由PEDV高致病性变异体引起的大规模PED,对全球养猪业构成巨大威胁。在许多研究中已经证明，经典的减毒疫苗株，PEDVCV777不足以完全防止PEDV变体。此外，灭活疫苗引发的母源抗体也不能完全保护仔猪免受感染。此外,反馈喂养在养猪场存在周期性PEDV复发的风险，这使得成功限制PEDV在中国的传播成为挑战。这篇综述的重点是病因，流行病学,抗原性,以及我国PEDV的控制策略,为制定有效的控制措施提供信息。
