Abstract：
Acanthosis nigricans (AN) is a cutaneous disorder identified by well-defined pigmented plaques mostly detected on skin folds. Timely diagnosis and treatment of AN is essential as it could be an early manifestation of an underlying condition. The treatment of choice for AN has not been determined yet. Our study aimed to compare the efficacy and safety of various lasers with topical medications, including cream and peel. PubMed, Scopus, and Web of Science databases, as well as the Google Scholar search engine, were thoroughly searched until May 1st, 2023. Study selection was restricted to clinical trials published in English language comparing lasers with topical treatments. This study followed the PRISMA guidelines for systematic reviews and meta-analyses. Out of 1748 studies, Six clinical trials met our inclusion criteria, with 133 patients. We examined laser therapies, including fractional CO2 laser, 1550-nm erbium fiber laser, and long-pulsed alexandrite laser, while the topical treatments comprised glycolic acid (GA) peel, retinoic acid peel, trichloroacetic acid (TCA) peel, and tretinoin cream. In two studies, GA peel demonstrated favorable results compared to fractional CO2 laser. Besides, fractional CO2 laser exhibited efficacy, surpassing TCA peel in AN management. Additionally, a fractional 1550-nm erbium fiber laser displayed superiority over tretinoin cream in reducing average roughness. Similarly, a long-pulsed alexandrite laser demonstrated its effectiveness in axillary AN treatment compared to the combination of tretinoin and ammonium lactate. Overall, the findings revealed that laser therapy was associated with superior results. Moreover, topical treatments are safe and efficacious in AN management.
摘要：
黑棘皮病（AN）是一种皮肤疾病，主要是在皮肤褶皱上检测到的明确定义的色素斑块。及时诊断和治疗AN至关重要，因为它可能是潜在疾病的早期表现。尚未确定AN的治疗选择。我们的研究旨在比较各种激光与局部药物的疗效和安全性，包括奶油和果皮。PubMed,Scopus,和WebofScience数据库,以及谷歌学者搜索引擎，被彻底搜查，直到5月1日，2023年。研究选择仅限于以英语发表的临床试验，比较激光与局部治疗。本研究遵循PRISMA指南进行系统评价和荟萃分析。在1748项研究中，六项临床试验符合我们的纳入标准，133名患者我们检查了激光治疗，包括分数二氧化碳激光，1550-nm铒光纤激光器，长脉冲翠绿宝石激光，而局部治疗包括乙醇酸（GA）剥离，维甲酸皮，三氯乙酸(TCA)果皮,和维甲酸奶油.在两项研究中，与分数CO2激光相比，GA剥离显示出良好的结果。此外,分数CO2激光表现出功效，在管理中超越TCA果皮。此外,分数为1550nm的铒光纤激光器在降低平均粗糙度方面优于维甲酸乳膏。同样，与维甲酸和乳酸铵的组合相比，长脉冲翠绿宝石激光证明了其在腋窝AN治疗中的有效性。总的来说,研究结果表明，激光治疗与优异的结果相关。此外，局部治疗在AN管理中是安全有效的。
