Abstract：
UNASSIGNED: At present, there are no available genetic data on the AGCU EX22 Kit from the Wuhu Han population.
UNASSIGNED: This study investigates the applicability of the AGCU EX22 kit, designed for the Chinese population for forensic analysis and population genetics of the Wuhu Han population.
UNASSIGNED: Bloodstains from 1565 unrelated healthy individuals in Wuhu city, Anhui Province, were collected for analysis. The AGCU EX22 kit was used for amplification, and capillary electrophoresis was used to separate the amplification products. Allele frequencies and forensic parameters were determined. The Wuhu Han population was compared to 10 reference populations through genetic distance, a phylogenetic neighbor-joining tree and principal component analysis.
UNASSIGNED: In total, 281 alleles and 1187 genotypes were observed. No significant deviations from Hardy-Weinberg equilibrium at any locus were found after Bonferroni\'s correction. The 21 autosomal short tandem repeat (STR) genetic markers exhibited high informativeness and polymorphism. The cumulative power of discrimination and power of exclusion were 0.999999999999999999999999913380 and 0.999999996752339, respectively. Population comparisons revealed a genetic affinity between Wuhu Han and southern Han populations, except for the Guangdong Han population, which aligned with the traditional geographical division in China.
UNASSIGNED: The AGCU EX22 Kit, containing 21 STR loci, is suitable for forensic application and population genetics studies in the Wuhu Han population.
UNASSIGNED: This study investigates the applicability of the AGCU EX22 kit, designed for the Chinese population for forensic analysis and population genetics of the Wuhu Han population.
UNASSIGNED: Bloodstains from 1565 unrelated healthy individuals in Wuhu city, Anhui Province, were collected for analysis. The AGCU EX22 kit was used for amplification, and capillary electrophoresis was used to separate the amplification products. Allele frequencies and forensic parameters were determined. The Wuhu Han population was compared to 10 reference populations through genetic distance, a phylogenetic neighbor-joining tree and principal component analysis.
UNASSIGNED: In total, 281 alleles and 1187 genotypes were observed. No significant deviations from Hardy-Weinberg equilibrium at any locus were found after Bonferroni\'s correction. The 21 autosomal short tandem repeat (STR) genetic markers exhibited high informativeness and polymorphism. The cumulative power of discrimination and power of exclusion were 0.999999999999999999999999913380 and 0.999999996752339, respectively. Population comparisons revealed a genetic affinity between Wuhu Han and southern Han populations, except for the Guangdong Han population, which aligned with the traditional geographical division in China.
UNASSIGNED: The AGCU EX22 Kit, containing 21 STR loci, is suitable for forensic application and population genetics studies in the Wuhu Han population.
摘要：
■目前，芜湖汉族人群的AGCUEX22试剂盒没有可用的遗传数据。
■本研究调查了AGCUEX22套件的适用性，为中国人群设计，用于芜湖汉族人群的法医分析和人群遗传学。
■芜湖市1565名无关健康人的血迹，安徽省,收集用于分析。AGCUEX22试剂盒用于扩增，用毛细管电泳分离扩增产物。确定等位基因频率和法医参数。通过遗传距离将芜湖汉族种群与10个参考种群进行比较,系统发育近邻连接树和主成分分析。
■总共，共观察到281个等位基因和1187个基因型。Bonferroni校正后，在任何位置均未发现Hardy-Weinberg平衡的显着偏差。21个常染色体短串联重复序列（STR）遗传标记具有较高的信息性和多态性。累积辨别力和排除力分别为0.9999999999999999999999999999913380和0.9999996752339。种群比较显示，芜湖汉族和南方汉族之间存在遗传亲和力，除了广东汉族，这与中国传统的地理划分相一致。
■AGCUEX22套件,含有21个STR基因座，适用于芜湖汉族人群的法医应用和群体遗传学研究。
■本研究调查了AGCUEX22套件的适用性，为中国人群设计，用于芜湖汉族人群的法医分析和人群遗传学。
■芜湖市1565名无关健康人的血迹，安徽省,收集用于分析。AGCUEX22试剂盒用于扩增，用毛细管电泳分离扩增产物。确定等位基因频率和法医参数。通过遗传距离将芜湖汉族种群与10个参考种群进行比较,系统发育近邻连接树和主成分分析。
■总共，共观察到281个等位基因和1187个基因型。Bonferroni校正后，在任何位置均未发现Hardy-Weinberg平衡的显着偏差。21个常染色体短串联重复序列（STR）遗传标记具有较高的信息性和多态性。累积辨别力和排除力分别为0.9999999999999999999999999999913380和0.9999996752339。种群比较显示，芜湖汉族和南方汉族之间存在遗传亲和力，除了广东汉族，这与中国传统的地理划分相一致。
■AGCUEX22套件,含有21个STR基因座，适用于芜湖汉族人群的法医应用和群体遗传学研究。
