PDF(Pubmed)
Abstract：
Yersiniosis is a common zoonotic enteric disease among humans, which has been linked to pigs and contaminated food, especially pork. The epidemiology of yersiniosis is still obscure, and studies on yersiniosis in pets are very scarce. In this study, we performed pheno- and genotypic characterisation of 50 Yersinia strains isolated from pets in Finland between 2012 and 2023. Y. enterocolitica 4/O:3/ST135, the most common type in human yersiniosis, was also the most common type (68%) found in clinical faecal samples in our study. Also, human pathogenic Y. enterocolitica 2/O:9/ST139 and Y. pseudotuberculosis O:1/ST9 and O:1/ST42 strains carrying all essential pathogenic genes were identified. Three Y. enterocolitica 4/O:3/ST9 strains were multi-drug-resistant and two of them were highly related, showing one allelic difference (AD) with core genome multi-locus sequence typing. Non-pathogenic, genotypically highly diverse Y. enterocolitica 1A strains, showing more than 1000 ADs and missing the essential virulence genes, were also recognised in dogs and cats. Our study demonstrates that pets can excrete human pathogenic Yersinia in their faeces and may serve as an infection source for human yersiniosis, especially in families with small children in close contact with their pets.
摘要：
耶尔森氏病是人类常见的人畜共患肠道疾病，与猪和受污染的食物有关，尤其是猪肉。耶尔森氏菌病的流行病学仍然不清楚，对宠物耶尔森氏菌病的研究非常匮乏。在这项研究中,我们对2012年至2023年间从芬兰宠物中分离出的50株耶尔森氏菌进行了表型和基因型鉴定.小肠结肠炎4/O：3/ST135，人类耶尔森氏菌病最常见的类型，也是我们研究中临床粪便样本中最常见的类型（68％）。此外，人类致病性小肠结肠炎2/O：9/ST139和假结核O：1/ST9和O：1/ST42菌株携带所有必需的致病基因。3株小肠结肠炎4/O:3/ST9菌株多重耐药，其中2株高度相关，核心基因组多位点序列分型显示一个等位基因差异(AD)。非致病性,基因型高度多样化的小肠结肠炎菌株1A，显示超过1000个AD并且缺少必需的毒力基因，在狗和猫中也被认可。我们的研究表明，宠物可以在粪便中排泄人类致病性耶尔森氏菌，并可能成为人类耶尔森氏菌病的感染源。特别是在有小孩与宠物密切接触的家庭中。
