PDF(Pubmed)
Abstract：
Tuberculosis (TB) of the central nervous system (CNS) is a lethal and incapacitating disease. Several studies have been performed to understand the mechanism of bacterial arrival to CNS, however, it remains unclear. Although the interaction of the host, the pathogen, and the environment trigger the course of the disease, in TB the characteristics of these factors seem to be more relevant in the genesis of the clinical features of each patient. We previously tested three mycobacterial clinical isolates with distinctive genotypes obtained from the cerebrospinal fluid of patients with meningeal TB and showed that these strains disseminated extensively to the brain after intratracheal inoculation and pulmonary infection in BALB/c mice. In this present study, BALB/c mice were infected through the intranasal route. One of these strains reaches the olfactory bulb at the early stage of the infection and infects the brain before the lungs, but the histological study of the nasal mucosa did not show any alteration. This observation suggests that some mycobacteria strains can arrive directly at the brain, apparently toward the olfactory nerve after infecting the nasal mucosa, and guides us to study in more detail during mycobacteria infection the nasal mucosa, the associated connective tissue, and nervous structures of the cribriform plate, which connect the nasal cavity with the olfactory bulb.
摘要：
中枢神经系统（CNS）的结核病（TB）是一种致命且致残的疾病。已经进行了一些研究来了解细菌到达CNS的机制，然而,目前还不清楚。虽然主机的相互作用，病原体，环境引发了疾病的进程，在结核病中，这些因素的特征似乎与每个患者的临床特征的发生更相关。我们先前测试了从脑膜TB患者的脑脊液中获得的三种具有独特基因型的分枝杆菌临床分离株，并表明这些菌株在BALB/c小鼠的气管内接种和肺部感染后广泛传播到大脑。在本研究中,通过鼻内途径感染BALB/c小鼠。这些菌株中的一种在感染的早期到达嗅球，并在肺部之前感染大脑，但是鼻粘膜的组织学研究没有显示任何改变。这一观察表明，一些分枝杆菌菌株可以直接到达大脑，感染鼻粘膜后明显朝向嗅神经，并指导我们在分枝杆菌感染期间更详细地研究鼻粘膜，相关的结缔组织，和筛板的神经结构，连接鼻腔和嗅球。
