PDF(Pubmed)
Abstract：
Mycotoxins are toxic metabolites of molds which can contaminate food and beverages. Because of their acute and chronic toxicity, they can have harmful effects when ingested or inhaled, posing severe risks to human health. Contemporary analytical methods have the sensitivity required for contamination detection and quantification, but the direct application of these methods on real samples is not straightforward because of matrix complexity, and clean-up and preconcentration steps are needed, more and more requiring the application of highly selective solid-phase extraction materials. Molecularly imprinted polymers (MIPs) are artificial receptors mimicking the natural antibodies that are increasingly being used as a solid phase in extraction methods where selectivity towards target analytes is mandatory. In this review, the state-of-the-art about molecularly imprinted polymers as solid-phase extraction materials in mycotoxin contamination analysis will be discussed, with particular attention paid to the use of mimic molecules in the synthesis of mycotoxin-imprinted materials, to the application of these materials to food real samples, and to the development of advanced extraction methods involving molecular imprinting technology.
摘要：
霉菌毒素是霉菌的有毒代谢产物，可以污染食品和饮料。由于其急性和慢性毒性，它们在摄入或吸入时会产生有害影响，对人类健康构成严重威胁。当代分析方法具有污染检测和定量所需的灵敏度，但是由于矩阵的复杂性，这些方法在实际样本上的直接应用并不简单，需要清理和预浓缩步骤，越来越需要应用高选择性的固相萃取材料。分子印迹聚合物（MIP）是模拟天然抗体的人工受体，这些天然抗体越来越多地用作提取方法中的固相，其中对目标分析物的选择性是强制性的。在这次审查中,将讨论分子印迹聚合物作为霉菌毒素污染分析中的固相萃取材料的最新技术，特别注意在真菌毒素印迹材料的合成中使用模拟分子，将这些材料应用于食品真实样品，以及涉及分子印迹技术的先进提取方法的开发。
