PDF(Pubmed)
Abstract：
Traumatic brain injury (TBI) is a common diagnosis requiring acute hospitalization. Long-term, TBI is a significant source of health and socioeconomic impact in the United States and globally. The goal of clinicians who manage TBI is to prevent secondary brain injury. In this population, post-traumatic cerebral infarction (PTCI) acutely after TBI is an important but under-recognized complication that is associated with negative functional outcomes. In this comprehensive review, we describe the incidence and pathophysiology of PTCI. We then discuss the diagnostic and treatment approaches for the most common etiologies of isolated PTCI, including brain herniation syndromes, cervical artery dissection, venous thrombosis, and post-traumatic vasospasm. In addition to these mechanisms, hypercoagulability and microcirculatory failure can also exacerbate ischemia. We aim to highlight the importance of this condition and future clinical research needs with the goal of improving patient outcomes after TBI.
摘要：
创伤性脑损伤（TBI）是需要急性住院的常见诊断。长期的,TBI是美国和全球健康和社会经济影响的重要来源。治疗TBI的临床医生的目标是预防继发性脑损伤。在这个人群中,TBI后急性外伤性脑梗死(PTCI)是一种重要但未得到充分认可的并发症,与负功能结局相关.在这次全面审查中，我们描述了PTCI的发病率和病理生理学。然后，我们讨论孤立性PTCI最常见病因的诊断和治疗方法，包括脑疝综合征，颈部动脉夹层,静脉血栓形成,创伤后血管痉挛.除了这些机制，高凝状态和微循环衰竭也会加剧缺血。我们的目标是强调这种情况的重要性和未来的临床研究需求，以改善TBI后患者的预后。
