PDF(Pubmed)
Abstract：
Billions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division. The process in which cells eliminate themselves in a controlled manner is called Programmed Cell Death (PCD). The PCD plays an important role during embryonic development, in maintaining homeostasis of the body\'s tissues, and in the elimination of damaged cells, under a wide range of physiological and developmental stimuli. A multitude of protein mediators of PCD have been identified and signals have been found to utilize common pathways elucidating the proteins involved. This narrative review focuses on caspase-dependent and caspase-independent PCD pathways. Included are studies of caspase-dependent PCD such as Anoikis, Catastrophe Mitotic, Pyroptosis, Emperitosis, Parthanatos and Cornification, and Caspase-Independent PCD as Wallerian Degeneration, Ferroptosis, Paraptosis, Entosis, Methuosis, and Extracellular Trap Abnormal Condition (ETosis), as well as neutrophil extracellular trap abnormal condition (NETosis) and Eosinophil Extracellular Trap Abnormal Condition (EETosis). Understanding PCD from those reported in this review could shed substantial light on the processes of biological homeostasis. In addition, identifying specific proteins involved in these processes is mandatory to identify molecular biomarkers, as well as therapeutic targets. This knowledge could provide the ability to modulate the PCD response and could lead to new therapeutic interventions in a wide range of diseases.
摘要：
每小时都有几十亿个细胞在我们体内死亡,我们的组织不会收缩，因为有一种自然调节，细胞死亡（CD）与细胞分裂平衡。细胞以受控方式消除自身的过程称为程序性细胞死亡(PCD)。PCD在胚胎发育过程中发挥着重要作用,在维持身体组织的稳态，在消除受损细胞的过程中，在广泛的生理和发育刺激下。已经鉴定了PCD的多种蛋白质介体,并且已经发现信号利用阐明所涉及的蛋白质的共同途径。这篇叙述性综述侧重于caspase依赖性和caspase非依赖性PCD途径。包括胱天蛋白酶依赖性PCD的研究，如Anoikis，巨灾有丝分裂，焦亡,精子症,Parthanatos和圣洁，和不依赖胱天蛋白酶的PCD作为华勒变性，Ferroptosis,上清液,上清液,Methuosis,和细胞外陷阱异常状况（ETosis），以及中性粒细胞胞外诱捕网异常情况(NETosis)和嗜酸性粒细胞胞外诱捕网异常情况(EETosis)。从这篇综述中报道的内容中了解PCD可以为生物稳态的过程提供实质性的启示。此外,识别参与这些过程的特定蛋白质是识别分子生物标志物的强制性要求，以及治疗目标。这些知识可以提供调节PCD反应的能力，并可以在多种疾病中产生新的治疗干预措施。
