PDF(Pubmed)
Abstract：
UNASSIGNED: Sleep is essential to all human body functions as well as brain functions. Inadequate sleep quantity and poor sleep quality have been shown to directly affect cognitive functioning and especially memory. The primary aim of the present study was to investigate the association of sleep quality with cognitive abilities cross-sectionally in a middle-aged Greek population and secondarily to examine this association prospectively in a smaller group of these participants.
UNASSIGNED: A total of 2112 healthy adults aged 25-70 years (mean: 46.7±11.5) from the Epirus Health Study cohort were included in the analysis and 312 of them participated in secondary prospective analysis. Sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI) scale and cognition was assessed in primary cross-sectional analyses with three neuropsychological tests, namely the Verbal Fluency test, the Logical Memory test and the Trail Making test, and in secondary prospective analyses with online versions of Posner cueing task, an emotional recognition task, the Corsi block-tapping task and the Stroop task. Statistical analysis was performed using multivariable linear regression models adjusted for age, sex, education, body mass index and alcohol consumption.
UNASSIGNED: Attention/processing speed was the only cognitive domain associated cross-sectionally with PSQI score. Specifically, participants with better self-reported sleep quality performed faster on the Trail Making Test - Part A (β= 0.272 seconds, 95% CI 0.052, 0.493).
UNASSIGNED: Further studies are needed to clarify the association of sleep quality with cognition, especially in middle-aged people that are still in productive working years.
UNASSIGNED: A total of 2112 healthy adults aged 25-70 years (mean: 46.7±11.5) from the Epirus Health Study cohort were included in the analysis and 312 of them participated in secondary prospective analysis. Sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI) scale and cognition was assessed in primary cross-sectional analyses with three neuropsychological tests, namely the Verbal Fluency test, the Logical Memory test and the Trail Making test, and in secondary prospective analyses with online versions of Posner cueing task, an emotional recognition task, the Corsi block-tapping task and the Stroop task. Statistical analysis was performed using multivariable linear regression models adjusted for age, sex, education, body mass index and alcohol consumption.
UNASSIGNED: Attention/processing speed was the only cognitive domain associated cross-sectionally with PSQI score. Specifically, participants with better self-reported sleep quality performed faster on the Trail Making Test - Part A (β= 0.272 seconds, 95% CI 0.052, 0.493).
UNASSIGNED: Further studies are needed to clarify the association of sleep quality with cognition, especially in middle-aged people that are still in productive working years.
摘要：
■睡眠对人体所有功能以及大脑功能都至关重要。睡眠量不足和睡眠质量差已被证明直接影响认知功能，尤其是记忆。本研究的主要目的是在中年希腊人群中横向调查睡眠质量与认知能力的关系，其次是在较小的参与者群体中前瞻性地检查这种关系。
■来自Epirus健康研究队列的2112名年龄在25-70岁（平均：46.7±11.5）的健康成年人被纳入分析，其中312人参与了二级前瞻性分析。通过匹兹堡睡眠质量指数（PSQI）量表测量睡眠质量，并通过三项神经心理学测试在主要横断面分析中评估认知能力。即口语流利度测试，逻辑记忆测试和跟踪测试，在带有在线版本的波斯纳提示任务的二次前瞻性分析中，情感识别任务，Corsi封锁任务和Stroop任务.统计分析是使用多变量线性回归模型进行调整的年龄，性别,教育,体重指数和饮酒量。
■注意力/处理速度是与PSQI评分交叉相关的唯一认知领域。具体来说,自我报告睡眠质量更好的参与者在示踪测试-A部分中表现更快(β=0.272秒，95%CI0.052，0.493）。
■需要进一步的研究来阐明睡眠质量与认知的关系，特别是在仍处于生产性工作年限的中年人中。
■来自Epirus健康研究队列的2112名年龄在25-70岁（平均：46.7±11.5）的健康成年人被纳入分析，其中312人参与了二级前瞻性分析。通过匹兹堡睡眠质量指数（PSQI）量表测量睡眠质量，并通过三项神经心理学测试在主要横断面分析中评估认知能力。即口语流利度测试，逻辑记忆测试和跟踪测试，在带有在线版本的波斯纳提示任务的二次前瞻性分析中，情感识别任务，Corsi封锁任务和Stroop任务.统计分析是使用多变量线性回归模型进行调整的年龄，性别,教育,体重指数和饮酒量。
■注意力/处理速度是与PSQI评分交叉相关的唯一认知领域。具体来说,自我报告睡眠质量更好的参与者在示踪测试-A部分中表现更快(β=0.272秒，95%CI0.052，0.493）。
■需要进一步的研究来阐明睡眠质量与认知的关系，特别是在仍处于生产性工作年限的中年人中。
