PDF(Pubmed)
Abstract：
This case report presents a comprehensive analysis of a 67-year-old patient diagnosed in 2017 with meningothelial meningioma, focusing on the challenges of managing such tumors and their neurological implications. Meningiomas, being the most common benign intracranial neoplasms, have a notable research gap regarding their association with seizures and motor deficits. This patient, who had a history of depressive disorder, persistent cephalalgia syndrome, and ataxic gait, initially presented with symptoms including ataxic gait, confusion, and headache. Imaging revealed a large, hyperdense right frontal meningioma with a significant mass effect. Following surgical resection, the patient experienced notable neurological improvement. However, in 2023, the patient re-presented with bradypsychia, bradykinesia, and memory disorders, indicating a recurrent meningioma. This case exemplifies the recurrence and complex management of meningiomas, particularly in elderly patients, and highlights the importance of individualized treatment strategies. Surgical resection remains the primary treatment approach, supplemented by radiotherapy in cases of recurrence or incomplete resection. The case underscores the need for advancements in therapeutic approaches to mitigate recurrence risks and enhance patient outcomes in meningioma management. This is especially pertinent given the tumor\'s predilection for older females and its varied neurological manifestations, such as ataxic gait and seizures.
摘要：
该病例报告提供了2017年诊断为脑膜上皮脑膜瘤的67岁患者的综合分析。重点关注管理此类肿瘤的挑战及其对神经系统的影响。脑膜瘤,作为最常见的良性颅内肿瘤，在它们与癫痫发作和运动缺陷的关系方面存在显著的研究差距。这个病人,有抑郁症病史的人，持续性头痛综合征,和共济失调步态，最初出现的症状包括共济失调步态，混乱,和头痛。成像显示，高密度右额叶脑膜瘤具有明显的质量效应。手术切除后,患者经历了显著的神经系统改善。然而,2023年，患者重新出现了缓释片，运动迟缓,和记忆障碍，提示脑膜瘤复发.这个案例说明了脑膜瘤的复发和复杂的治疗，尤其是老年患者，并强调了个性化治疗策略的重要性。手术切除仍然是主要的治疗方法，在复发或切除不完全的情况下辅以放疗。该案例强调了在脑膜瘤管理中需要改进治疗方法以减轻复发风险并提高患者预后。考虑到肿瘤对老年女性的偏爱及其各种神经系统表现，这一点尤其相关。如共济失调步态和癫痫发作。
