PDF(Pubmed)
Abstract：
Frontal Fibrosing Alopecia (FFA) is a distinctive form of cicatricial alopecia characterized by gradual hairline recession, predominantly affecting postmenopausal individuals, thus implying a potential hormonal origin. This narrative review, spanning 2000 to 2023, delves into PubMed literature, focusing on the menopausal and hormonal status of women with FFA. The objective is to unravel the intricate nature of FFA and its plausible associations with hormonal dysregulations in women. While menopause remains a pivotal demographic characteristic linked to FFA, existing data suggest that its hormonal imbalances may not fully account for the development of FFA. Conversely, substantial evidence indicates a strong association between a reduction in fertile years, particularly through surgical interventions leading to an abrupt hormonal imbalance, and FFA in women. Additionally, exposure to hormone replacement therapy or oral contraceptives has shown varying degrees of association with FFA. Gynecologists should maintain a heightened awareness regarding the ramifications of their interventions and their pivotal role in overseeing women\'s fertility, recognizing the potential influence on the progression of FFA. The recurrent theme of hormonal disruption strongly implies a causal connection between alterations in sex hormones and FFA in women. Nevertheless, this relationship\'s extent and underlying mechanisms remain subjects of ongoing debate.
摘要：
额叶纤维性脱发（FFA）是瘢痕性脱发的一种独特形式，其特征是发际线逐渐衰退，主要影响绝经后个体，因此暗示潜在的荷尔蒙起源。这篇叙述性评论，从2000年到2023年，深入研究PubMed文学，关注FFA女性的更年期和荷尔蒙状况。目的是揭示FFA的复杂性质及其与女性荷尔蒙失调的合理联系。虽然更年期仍然是与FFA相关的关键人口统计学特征，现有数据表明，其激素失衡可能不能完全解释FFA的发展。相反，大量证据表明，肥沃年限减少之间存在很强的关联，特别是通过外科手术导致突然的荷尔蒙失衡，FFA在女性此外,激素替代疗法或口服避孕药暴露与FFA有不同程度的关联.妇科医生应提高对干预措施的影响及其在监督妇女生育方面的关键作用的认识，认识到对FFA进展的潜在影响。荷尔蒙中断的反复出现的主题强烈暗示了女性性激素变化与FFA之间的因果关系。然而，这种关系的程度和潜在机制仍然是正在进行辩论的主题。
