PDF(Pubmed)
Abstract：
Mature vascular smooth muscle cells (VSMC) exhibit a remarkable degree of plasticity, a characteristic that has intrigued cardiovascular researchers for decades. Recently, it has become increasingly evident that the chromatin remodeler SWItch/Sucrose Non-Fermentable (SWI/SNF) complex plays a pivotal role in orchestrating chromatin conformation, which is critical for gene regulation. In this review, we provide a summary of research related to the involvement of the SWI/SNF complexes in VSMC and cardiovascular diseases (CVD), integrating these discoveries into the current landscape of epigenetic and transcriptional regulation in VSMC. These novel discoveries shed light on our understanding of VSMC biology and pave the way for developing innovative therapeutic strategies in CVD treatment.
摘要：
成熟的血管平滑肌细胞（VSMC）表现出明显的可塑性，几十年来一直吸引着心血管研究人员的特征。最近,越来越明显的是，染色质重塑剂SWItch/蔗糖不可发酵（SWI/SNF）复合物在协调染色质构象中起着关键作用，这对基因调控至关重要。在这次审查中,我们提供了有关SWI/SNF复合物在VSMC和心血管疾病（CVD）中的参与的研究综述，将这些发现整合到VSMC中表观遗传和转录调控的当前景观中。这些新发现揭示了我们对VSMC生物学的理解，并为开发CVD治疗的创新治疗策略铺平了道路。
