PDF(Pubmed)
Abstract：
Foodborne infections pose a substantial global threat, causing an estimated 600 million illnesses and resulting in approximately 420,000 deaths annually. Among the diverse array of pathogens implicated in these infections, Escherichia coli (E. coli), specifically the O157 strain (E. coli O157), emerges as a prominent pathogen associated with severe outbreaks. This study employs a comprehensive bibliometric analysis and scholarly review focused on E. coli O157 research. The bibliometric analysis highlights the significant role played by the United States in the E. coli O157 research domain. Further exploration underscores the noteworthy contributions of the researcher Doyle MP, whose body of work, consisting of 84 documents and an impressive H-Index of 49, reflects their substantial impact in the field. Recent research trends indicate a discernible shift towards innovative detection methods, exemplified by the adoption of CRISPR-CAS and Loop-Mediated Isothermal Amplification. Moreover, high-throughput whole-genome sequencing techniques are gaining prominence for the expeditious analysis of pathogenic E. coli strains. Scientists are increasingly exploring antimicrobial agents, including phage therapy, to address the challenges posed by antibiotic-resistant E. coli strains, thereby addressing critical concerns related to multi-drug resistance. This comprehensive analysis provides vital insights into the dynamic landscape of E. coli O157 research. It serves as a valuable resource for researchers, policymakers, and healthcare professionals dedicated to mitigating E. coli O157 outbreaks and advancing global public health strategies.
摘要：
食源性感染构成了巨大的全球威胁，估计造成6亿例疾病，每年约有42万人死亡。在与这些感染有关的各种病原体中，大肠杆菌(E.大肠杆菌)，特别是O157菌株(E.大肠杆菌O157)，作为与严重疫情相关的突出病原体出现。本研究采用了全面的文献计量分析和学术综述，重点是大肠杆菌O157研究。文献计量分析强调了美国在大肠杆菌O157研究领域发挥的重要作用。进一步的探索强调了研究人员DoyleMP的值得注意的贡献，谁的工作，由84份文件和令人印象深刻的49H指数组成，反映了它们在该领域的巨大影响。最近的研究趋势表明，朝着创新的检测方法发生了明显的转变，以采用CRISPR-CAS和环介导等温扩增为例。此外，高通量全基因组测序技术在快速分析致病性大肠杆菌菌株方面越来越重要。科学家们越来越多地探索抗菌剂，包括噬菌体疗法,为了应对抗生素抗性大肠杆菌菌株带来的挑战，从而解决了与多药耐药性相关的关键问题。这种全面的分析为大肠杆菌O157研究的动态前景提供了重要的见解。它是研究人员的宝贵资源，政策制定者，以及致力于缓解大肠杆菌O157爆发和推进全球公共卫生战略的医疗保健专业人员。
